The Lancet Planetary Health, Volume 5, June 2021

Temperature affects many life processes, but its effect might be expected to differ among eukaryotic organisms inhabiting similar environments.

A Commentary on the role of governments in mitigating the health effects of malnutrition, in the context of SDGs 3 and 12, highlighting the need for the implementation of more comprehensive policies to limit the availability of unhealthy foods and to increase that of healthy foods to communities across Africa.
Background: The COVID-19 pandemic has affected mental health, psychological wellbeing, and social interactions.
The pharmacologic parameters that drive optimal HIV latency reversal in vivo are unknown and could be influenced by such factors as the HDACi binding kinetics, concentration of compound, and duration of exposure. This study evaluates how these parameters affect HIV latency reversal for a series of novel HDACis that differ in their enzymatic on and off rates. The comprehensive data set generated by automating the assays described here was used to establish a PK/PD model for HDACi-induced HIV latency reversal.
Main participants in a PPP—core strengths and key benefits in drug discovery/development. The figure provides an overview of the main participants in a PPP, highlights their core strengths, and lists important benefits across the various stages of the dru
Collaborative efforts between public and private entities such as academic institutions, governments, and pharmaceutical companies form an integral part of scientific research, and notable instances of such initiatives have been created within the life science community. Several examples of alliances exist with the broad goal of collaborating toward scientific advancement and improved public welfare. Such collaborations can be essential in catalyzing breaking areas of science within high-risk or global public health strategies that may have otherwise not progressed. A common term used to describe these alliances is public-private partnership (PPP). This review discusses different aspects of such partnerships in drug discovery/development and provides example applications as well as successful case studies. Specific areas that are covered include PPPs for sharing compounds at various phases of the drug discovery process—from compound collections for hit identification to sharing clinical candidates. Instances of PPPs to support better data integration and build better machine learning models are also discussed. The review also provides examples of PPPs that address the gap in knowledge or resources among involved parties and advance drug discovery, especially in disease areas with unfulfilled and/or social needs, like neurological disorders, cancer, and neglected and rare diseases.
Elsevier, Transportation Research Part E: Logistics and Transportation Review, Volume 149, May 2021
In this paper, we address the problem of humanitarian aids distribution across refugee camps in war-ridden areas from a network design perspective.
Problem: Today, one in four children in the world lives in an area of conflict or disaster, and more than 30 million have been displaced, enslaved or trafficked, abused, and exploited.

After a massive disaster, many residents in affected areas are forced to temporarily stay in evacuation shelters.