Re-definition and supporting evidence toward Fanconi Anemia as a mitochondrial disease: Prospects for new design in clinical management
Redox Biology, Volume 40, April 2021
Fanconi anemia (FA) has been investigated since early studies based on two definitions, namely defective DNA repair and proinflammatory condition. The former definition has built up the grounds for FA diagnosis as excess sensitivity of patients’ cells to xenobiotics as diepoxybutane and mitomycin C, resulting in typical chromosomal abnormalities. Another line of studies has related FA phenotype to a prooxidant state, as detected by both in vitro and ex vivo studies. The discovery that the FA group G (FANCG) protein is found in mitochondria (Mukhopadhyay et al., 2006) has been followed by an extensive line of studies providing evidence for multiple links between other FA gene products and mitochondrial dysfunction. The fact that FA proteins are encoded by nuclear, not mitochondrial DNA does not prevent these proteins to hamper mitochondrial function, as it is recognized that most mitochondrial proteins are of nuclear origin. This body of evidence supporting a central role of mitochondrial dysfunction, along with redox imbalance in FA, should lead to the re-definition of FA as a mitochondrial disease.
Elsevier, The Lancet Public Health, Volume 6, March 2021
Ethnic inequalities in health-related quality of life among older adults in England: secondary analysis of a national cross-sectional survey
Background: The population of older adults (ie, those aged ≥55 years) in England is becoming increasingly ethnically diverse.
Elsevier, The Lancet Digital Health, Volume 3, March 2021
Elsevier, Clinics in Chest Medicine, Volume 42, March 2021
Pulmonary arterial hypertension (PAH) occurs in women more than men whereas survival in men is worse than in women.
Elsevier, The Lancet Planetary Health, Volume 5, March 2021
Background: Ambient air pollution is a major environmental cause of morbidity and mortality worldwide. Cities are generally hotspots for air pollution and disease.
Elsevier, Geography and Sustainability, Volume 2, March 2021
Integrate ecosystem services into socio-economic development to enhance achievement of sustainable development goals in the post-pandemic era
The COVID-19 pandemic has stalled and rolled back progress on Sustainable Development Goals (SDGs).
Elsevier, Journal of the American Academy of Dermatology, Volume 84, March 2021
Elsevier, Behavioural Brain Research, Volume 402, 26 March 2021
Effects of melatonin and resveratrol on recognition memory and passive avoidance performance in a mouse model of Alzheimer's disease
Alzheimer's disease (AD) is the foremost cause of dementia among other neurodegenerative diseases, leading to memory loss and cognitive deficits.
Elsevier, Biomedical Signal Processing and Control, Volume 65, March 2021
Background: Alzheimer's disease (AD) is a progressive neurodegenerative disorder of the brain that ultimately results in the death of neurons and dementia.
Elsevier, JAAD International, Volume 2, March 2021
Burden of skin disease and associated socioeconomic status in Asia: A cross-sectional analysis from the Global Burden of Disease Study 1990-2017
Introduction: Skin diseases have a significant global impact on quality of life, mental health, and loss of income.