This Research paper supports SDGs 3 and 10 by assessing ethnic differences in SARS-CoV-2 seropositivity among hospital workers. The findings showed that Black people had more than double the likelihood of SARS-CoV-2 seropositivity compared with White people, independent of age, sex, socioeconomic factors, and hospital role.
This Comment article supports SDGs 3, 10, and 17 by highlighting the need for full inclusivity and representation, and the involvement of a diverse range of stakeholders and voices, in order to successfully design solutions to global health problems and to reform the systems that are exacerbating global health inequities.
Background: Increasing access to hepatitis C virus (HCV) care and treatment will require simplified service delivery models.
In the β-thalassemias, oxidative stress, resulting from chronic hemolysis, globin chain imbalance, iron overload and depleted antioxidant defences, likely contributes to cell death, organ damage, anemia, hypoxia and inflammation. We assessed variations in these parameters in β-thalassemia syndromes in Sri Lanka.
Fanconi anemia (FA) has been investigated since early studies based on two definitions, namely defective DNA repair and proinflammatory condition. The former definition has built up the grounds for FA diagnosis as excess sensitivity of patients’ cells to xenobiotics as diepoxybutane and mitomycin C, resulting in typical chromosomal abnormalities. Another line of studies has related FA phenotype to a prooxidant state, as detected by both in vitro and ex vivo studies. The discovery that the FA group G (FANCG) protein is found in mitochondria (Mukhopadhyay et al., 2006) has been followed by an extensive line of studies providing evidence for multiple links between other FA gene products and mitochondrial dysfunction. The fact that FA proteins are encoded by nuclear, not mitochondrial DNA does not prevent these proteins to hamper mitochondrial function, as it is recognized that most mitochondrial proteins are of nuclear origin. This body of evidence supporting a central role of mitochondrial dysfunction, along with redox imbalance in FA, should lead to the re-definition of FA as a mitochondrial disease.
Background: The population of older adults (ie, those aged ≥55 years) in England is becoming increasingly ethnically diverse.
Pulmonary arterial hypertension (PAH) occurs in women more than men whereas survival in men is worse than in women.
Background: Ambient air pollution is a major environmental cause of morbidity and mortality worldwide. Cities are generally hotspots for air pollution and disease.
The COVID-19 pandemic has stalled and rolled back progress on Sustainable Development Goals (SDGs).
