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In the β-thalassemias, oxidative stress, resulting from chronic hemolysis, globin chain imbalance, iron overload and depleted antioxidant defences, likely contributes to cell death, organ damage, anemia, hypoxia and inflammation. We assessed variations in these parameters in β-thalassemia syndromes in Sri Lanka.
![Chromosomal instability, as a hallmark of FA, is viewed as a multiple outcome of: a) crosslinker activity of redox-related xenobiotics and b) cellular and organismal prooxidant state.](https://sdgresources.relx.com/sites/default/files/styles/sus_content_listing_image/public/re-definition_and_supporting_evidence.jpg?itok=uC4KRPYH)
Fanconi anemia (FA) has been investigated since early studies based on two definitions, namely defective DNA repair and proinflammatory condition. The former definition has built up the grounds for FA diagnosis as excess sensitivity of patients’ cells to xenobiotics as diepoxybutane and mitomycin C, resulting in typical chromosomal abnormalities. Another line of studies has related FA phenotype to a prooxidant state, as detected by both in vitro and ex vivo studies. The discovery that the FA group G (FANCG) protein is found in mitochondria (Mukhopadhyay et al., 2006) has been followed by an extensive line of studies providing evidence for multiple links between other FA gene products and mitochondrial dysfunction. The fact that FA proteins are encoded by nuclear, not mitochondrial DNA does not prevent these proteins to hamper mitochondrial function, as it is recognized that most mitochondrial proteins are of nuclear origin. This body of evidence supporting a central role of mitochondrial dysfunction, along with redox imbalance in FA, should lead to the re-definition of FA as a mitochondrial disease.
Elsevier,
Reciprocal Translation Between Pathophysiology and Practice in Health and Disease, 2021, Pages 93-107
This chapter aligns with the SDG goal 3 of good health and wellbeing by showing the role of the gut microbiota on liver function, disease, and inflammation.
This chapter reviews mental and physical health consequences for members of households with an established culture of violence, highlighting their heightened vulnerabilities and need for tailored resources during times of increased stress such as the pandemic.
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April 7th of each year marks the celebration of World Health Day. From its inception at the First Health Assembly in 1948 and since taking effect in 1950, the celebration has aimed to create awareness of a specific health theme to highlight a priority area of concern for the World Health Organization. To raise awareness of this year's theme - building a fairer, healthier world for everyone - Elsevier presents a curated list of free access journal articles and book chapters.
A Commentary on the Healthy People 2030 roadmap, in the context of SDGs 3 and 10, focusing specifically on the potential of this initiative in addressing upstream determinants of health to achieve health equity across the USA.
This book chapter advances SDGs 3, 12, and 13 by discussing carbonaceous aerosols that are one of the important components of the aerosol and play a significant role in changing climate, fluctuating air quality and health of the living being.
This book chapter advances SDGs 3, 12 and 13 by discussing the entrance of microplastics in a range of environments, including oceans, surface waters, wastewaters, soils, sediments, the atmosphere, and food.
This chapter advances the UN SDG goal 3 and 17 in understanding Alzheimer's disease at the cellular level
This chapter advances the UN SDG goal 3 and 17 in exploring the link between metabolites of shikimate pathway and Alzheimer disease