Obsessive-compulsive disorder is a severe and disabling psychiatric disorder that presents several challenges for neuroscience.
Here, Nestler and Lüscher link addiction circuits to epigenetic mechanisms that are engaged by drug exposure or reflect life experience.
Threat processing is central to understanding debilitating fear- and trauma-related disorders such as posttraumatic stress disorder (PTSD).
Perinatal depression (PND) is a heterogeneous disorder with differences in timing of onset of depression, which influences symptomology, severity, and treatment efficacy.
This paper highlights a rea case of hepatitis infection with HBV genotype D, with the purpose to investigate the molecular characteristics of a rare HBV subgenotype D4 isolate.
This book chapter advances SDGs 3 and 17 by reviewing the neurochemical aspects of Alzheimer’s type of Dementia.
Elsevier,
Aging, Nutrition and Taste: Nutrition, Food Science and Culinary Perspectives for Aging Tastefully, 2019, Pages xi-xvi
The aging process changes the sensory sciences and can lead to malnutrition as eating becomes less pleasurable. This chapter explores how optimising food taste works toward ensuing ongoing good nutrition and health, contributing to SDGs 2 and 3.
Elsevier,
Sex Differences in Cardiovascular Physiology and Pathophysiology, Academic Press, 2019, Pages 185-201
This book chapter addresses SDG 3 and 5 by reviewing the differences in awareness, risk factors, pathophysiology, clinical presentation, diagnostic evaluation, and management between men and women with coronary artery disease (CAD).
Cystic fibrosis is a genetic disease affecting more than 70,000 people worldwide. Caused by a mutation in the CFTR gene, cystic fibrosis can result in difficulty breathing, widespread bacterial infections, edema, malnutrition, pancreatitis, and death. Current drug-based treatments struggle to reach the site of action due to the thick mucus, and only manage symptoms such as blocked airways, lung infections, and limited ability to digest food. Nanotechnology opens up possibilities for improved treatment strategies by focusing on drug penetration through the mucus lining, eliminating resulting bacterial infections, and targeting the underlying genetic cause of the disease. In this review, we present recent nanoparticle developments for cystic fibrosis, challenges in nanomedicine therapeutics, and future research directions in gene editing and nonviral vectors for gene delivery.
