Fanconi anemia (FA) has been investigated since early studies based on two definitions, namely defective DNA repair and proinflammatory condition. The former definition has built up the grounds for FA diagnosis as excess sensitivity of patients’ cells to xenobiotics as diepoxybutane and mitomycin C, resulting in typical chromosomal abnormalities. Another line of studies has related FA phenotype to a prooxidant state, as detected by both in vitro and ex vivo studies. The discovery that the FA group G (FANCG) protein is found in mitochondria (Mukhopadhyay et al., 2006) has been followed by an extensive line of studies providing evidence for multiple links between other FA gene products and mitochondrial dysfunction. The fact that FA proteins are encoded by nuclear, not mitochondrial DNA does not prevent these proteins to hamper mitochondrial function, as it is recognized that most mitochondrial proteins are of nuclear origin. This body of evidence supporting a central role of mitochondrial dysfunction, along with redox imbalance in FA, should lead to the re-definition of FA as a mitochondrial disease.
This paper briefly reviews different debates about approaches for paths out of poverty, considering several views, from the analysis of specific policies to more general or systemic considerations.
To mark World Health Day 2021, RELX’s Global Head of Corporate Responsibility, Dr Márcia Balisciano, talks to Dr Richard McCallum and Dr Erika Claud about the need for a fairer and healthier world for all.
Elsevier,
Reciprocal Translation Between Pathophysiology and Practice in Health and Disease, 2021, Pages 93-107
This chapter aligns with the SDG goal 3 of good health and wellbeing by showing the role of the gut microbiota on liver function, disease, and inflammation.
This chapter reviews mental and physical health consequences for members of households with an established culture of violence, highlighting their heightened vulnerabilities and need for tailored resources during times of increased stress such as the pandemic.
Nexis Newsdesk™ has created graphics on the SDGs and the Global Media Landscape, offering charts & insights into global media coverage of the Sustainable Development Goals. View findings for Global Goal 7.
Nexis Newsdesk™ has created graphics on the SDGs and the Global Media Landscape, offering charts & insights into global media coverage of the Sustainable Development Goals. View findings for Global Goal 10.
Nexis Newsdesk™ has created graphics on the SDGs and the Global Media Landscape, offering charts & insights into global media coverage of the Sustainable Development Goals. View findings for Global Goal 13.
Nexis Newsdesk™ has created graphics on the SDGs and the Global Media Landscape, offering charts & insights into global media coverage of the Sustainable Development Goals. View findings for Global Goal 14.
April 7th of each year marks the celebration of World Health Day. From its inception at the First Health Assembly in 1948 and since taking effect in 1950, the celebration has aimed to create awareness of a specific health theme to highlight a priority area of concern for the World Health Organization. To raise awareness of this year's theme - building a fairer, healthier world for everyone - Elsevier presents a curated list of free access journal articles and book chapters.
