The present numerical study investigated the transportation time of the inhaled chemicals in three realistic human airway models by adopting a methodology from the field of the building ventilation. Two indexes including “scale of ventilation efficiency 3 (SVE3)” and “local purging flow rate (L-PFR)” were used to evaluate the respective arrival time and staying time under different inhalation flow rates.
Elsevier,
Recent Advancements in Microbial Diversity, Macrophages and Their Role in Inflammation, 2022, Pages 361-395
This chapter aligns with the SDG goal 3 of good health and wellbeing by showing the current knowledge on the origins and composition of KCs, their functions in maintaining hepatic homeostasis, and their involvement in both promoting and resolving liver inflammation, injury, and fibrosis.
This Comment supports SDGs 3 and 10 by highlighting the role of data scientists in challenging racism and discrimination. The Comment highlights how structural inequalities in society are easily encoded in datasets and in the application of data science, which can reinforce existing injustices.
This Viewpoint supports SDGs 3, 6, and 7 by discussing some of the reasons why many of the innovations and technologies for WASH (water, sanitation, and hygiene) and household air pollution developed in recent decades have not led to the expected improvements in health outcomes, and why many of these interventions have either been inconsistently adopted by low-income households, or not adopted at all.
Elsevier,
Understanding Female Offenders, Psychopathy, Criminal Behavior, Assessment, and Treatment, 2021, Pages 33-112
This chapter advances goals 3 and 5 by examining the range of common misconceptions and misinformation that permeates the female offender literature. Finally, we conclude with ten myths about female offenders and offer guidelines for identifying bias and how to avoid it.
In this episode of the “World We Want” podcast series, RELX’s Global Head of Corporate Responsibility, Dr. Márcia Balisciano, talks to Irina Bokova about leadership.
Intensifying air pollution has engendered growing public health concerns due to its broad and adverse effects on humanity. As a result, the development of air filtration technologies has received increased attention as a practical and promising solution. Till now, many efforts have sought to advance air filtration technologies to overcome the trade-off relationship between filtration efficiency and pressure drop.
Climate change can have detrimental effects on child health and wellbeing. Despite the imperative for a fuller understanding of how climate change affects child health and wellbeing, a systematic approach and focus solely on children (aged <18 years) has been lacking. In this Scoping Review, we did a literature search on the impacts of climate change on child health from January, 2000, to June, 2019. The included studies explicitly linked an alteration of an exposure to a risk factor for child health to climate change or climate variability.
Tauopathies are neurological disorders characterized by intracellular tau deposits forming neurofibrillary tangles, neuropil threads, or other disease-specific aggregates composed of the protein tau. Tauopathy disorders include frontotemporal lobar degeneration, corticobasal degeneration, Pick’s disease, and the largest cause of dementia, Alzheimer’s disease. The lack of disease-modifying therapeutic strategies to address tauopathies remains a critical unmet need in dementia care. Thus, novel broad-spectrum tau-targeted therapeutics could have a profound impact in multiple tauopathy disorders, including Alzheimer’s disease. Here we have designed a drug discovery paradigm to identify inhibitors of the pathological tau-enabling protein, MSUT2. We previously showed that activity of the RNA-binding protein MSUT2 drives tauopathy, including tau-mediated neurodegeneration and cognitive dysfunction, in mouse models. Thus, we hypothesized that MSUT2 inhibitors could be therapeutic for tauopathy disorders.
Material depletion over reliance of linear economies and environmental pollution may be resolved by applying the principles and practices of anthropogenic circularity science. Here we systematically review the emergence of anthropogenic circularity science in the interdisciplinary development of green chemistry, supply chain, and industrial ecology at different scales.
