Elsevier, Environment International, Volume 199, May 2025
Microplastic (MP) pollution has become a widespread environmental threat which must be addressed as it affects the water bodies, soil as well as air. MPs originally from synthetic textiles, tire abrasion, plastic waste, etc. pose the significant risks to both the environment and health due to its structure, ability to absorb toxins and act as carriers of harmful substances. This characteristic enables MPs to accumulate toxic substances and spread them within the food chain which leads to adverse effects on both the environment and human health including possible endocrine disruption.
Elsevier, One Earth, Volume 8, 16 May 2025
Flood, a natural disaster closely related to global climate change, harms child health. However, the long-term effect of flood exposure on child mortality is unknown, particularly in low- and middle-income countries (LMICs). Here, based on a sibling-matched case-control design and exposure data of 913 large flood events, we first estimate the under-5 deaths (U5Ds) attributable to long-term flood exposure in 100 LMICs, where there are >90% of global U5Ds.
Elsevier, Neuron, Volume 113, 7 May 2025
Changes in β-amyloid (Aβ) and hyperphosphorylated tau (T) in brain and cerebrospinal fluid (CSF) precede Alzheimer's disease (AD) symptoms, making the CSF proteome a potential avenue to understand disease pathophysiology and facilitate reliable diagnostics and therapies. Using the AT framework and a three-stage study design (discovery, replication, and meta-analysis), we identified 2,173 analytes (2,029 unique proteins) dysregulated in AD. Of these, 865 (43%) were previously reported, and 1,164 (57%) are novel.
Elsevier,
Journal of Communication Disorders, Volume 115, 1 May 2025
This systematic review examined the relationship between cognition and motor speech production in healthy older adults and those with mild cognitive impairment, analyzing 22 studies with 747 participants. Findings suggest that cognitive functions, particularly attention and executive abilities, are linked to motor speech performance, though evidence quality varies and gaps remain.
Elsevier,
Med, Volume 6, 9 May 2025
Real-world evidence can supplement clinical trial data to optimize Alzheimer’s disease care by aiding early patient identification and assessing drug effectiveness and safety in everyday use in diverse clinical settings/populations. This information helps inform clinical practice guidelines and supports the development of tools for timely diagnosis and personalized treatment strategies.
Elsevier,
Pharmacological Research, Volume 215, May 2025
The article discusses the role of gut dysbiosis, bacterial amyloids, and metabolic diseases in the development and progression of Alzheimer's disease (AD). It highlights the bidirectional relationship between the gut microbiome, inflammation, and metabolic disorders, and how these interconnected pathways contribute to neurodegeneration. The review explores potential therapeutic strategies targeting the gut-brain-metabolic axis to mitigate AD progression.
Elsevier,
Pharmacological Research, Volume 215, May 2025
The article provides a comprehensive review of the role of semaphorin 3A (Sema3A) in the pathogenesis and progression of Alzheimer's disease and other aging-related diseases. It discusses the expression patterns and mechanisms of action of Sema3A in various age-related disorders, including its involvement in oxidative stress, inflammatory responses, apoptosis, and synaptic plasticity.
Elsevier, iScience, Volume 28, 16 May 2025
This article examines 42,291 renewable energy investment deals across OECD countries from 2004 to 2022, revealing highly international capital flows. Results show that $US 45.4B annually (45%) is invested across borders, with varying degrees between countries. Further, renewable energy investments increasingly mirror general foreign direct investment (89% correlation), indicating financial mainstreaming, which can contribute to rapid deployment.
