Articles

Targeting CD38 to alleviate brain endothelial cell dysfunction and cognitive impairment in vascular dementia

Elsevier,

Journal of Pharmacological Sciences, Volume 158, Issue 4, August 2025, Pages 310-321

The article investigates the role of CD38, an enzyme implicated in neuroinflammation and cellular senescence, in the context of vascular dementia (VaD). It demonstrates that inhibiting CD38 can mitigate cerebrovascular endothelial cell dysfunction, blood-brain barrier disruption, neuroinflammation, and white matter damage, ultimately alleviating cognitive impairment in a mouse model of VaD. The findings suggest that targeting CD38 may offer a promising therapeutic strategy for addressing the vascular and neurological deficits associated with VaD

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SDG:

Goal 3: Good health and well-being

Tags:

Health and population; Health and wellbeing, Global

Diet-Related Health Inequalities in High-Income Countries: A Scoping Review of Observational Studies

Elsevier,

Advances in Nutrition , 2025, 100439

This scoping review examines diet-related health inequalities in high-income countries through the lens of the PROGRESS-Plus framework. It highlights the need for standardized methodologies and intersectional approaches to monitor and address persistent diet-related health inequalities in high-income countries

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SDG:

Goal 5: Gender equality; Goal 10: Reduced inequalities

Tags:

Educational inequality, Global

New ADAM Program Interactive Dashboard to Help Recover Missing Children

LexisNexis Risk Solutions,

adamprogram.com

A New Interactive Tool Empowers the Public to Search Geo-Targeted Missing Children Alerts Being Distributed Through the ADAM Program. The Dashboard Was Released in Honor of National Missing Children’s Day.

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SDG:

Goal 16: Peace, justice and strong institutions

Tags:

missing children; Community Engagement; public safety; child safety, Global

Supercritical water gasification for hospital wastewater

Elsevier,

Journal of Hazardous Materials Advances, Volume 18, May 2025

The research presented provides a comprehensive review of the potential of supercritical water gasification (SCWG) as a novel solution for treating complex and hazardous hospital wastewater.
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SDG:

Goal 6: Clean water and sanitation; Goal 13: Climate action; Goal 3: Good health and well-being

Tags:

Water and sanitation, Global

Multi-cohort cerebrospinal fluid proteomics identifies robust molecular signatures across the Alzheimer disease continuum

Elsevier, Neuron, Volume 113, 7 May 2025
Changes in β-amyloid (Aβ) and hyperphosphorylated tau (T) in brain and cerebrospinal fluid (CSF) precede Alzheimer's disease (AD) symptoms, making the CSF proteome a potential avenue to understand disease pathophysiology and facilitate reliable diagnostics and therapies. Using the AT framework and a three-stage study design (discovery, replication, and meta-analysis), we identified 2,173 analytes (2,029 unique proteins) dysregulated in AD. Of these, 865 (43%) were previously reported, and 1,164 (57%) are novel.
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SDG:

Goal 3: Good health and well-being

Tags:

Health and wellbeing, Global

Cognitive function and associations with demographic, socioeconomic, health and behavioural factors among older adult men and women in rural Bangladesh: a population-based cross-sectional study

Elsevier,

The Lancet Regional Health - Southeast Asia, Volume 36, May 2025

 Empirical evidence on cognitive function and its association with demographic, socioeconomic, health and behavioural factors among older adults in rural Bangladesh.
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SDG:

Goal 3: Good health and well-being; Goal 10: Reduced inequalities

Tags:

Health and wellbeing, Asia

Advancements in 3D models for studying human iPSC-microglia: Insights into neurodevelopment and neurological disorders

Elsevier,

hLife, Volume 3, May 2025

The article discusses advancements in using 3D models and human iPSC-derived microglia to study neurodevelopment and neurological disorders, highlighting their potential for understanding brain development, microglial functions, and disease mechanisms. It also explores various models, including organoids and xenotransplantation, and their applications in studying conditions like Alzheimer’s, Parkinson’s, and autism.
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SDG:

Goal 3: Good health and well-being

Tags:

Health and wellbeing, Global

A systematic review of the relationships amongst older adults’ cognitive and motor speech abilities

Elsevier,

Journal of Communication Disorders, Volume 115, 1 May 2025

This systematic review examined the relationship between cognition and motor speech production in healthy older adults and those with mild cognitive impairment, analyzing 22 studies with 747 participants. Findings suggest that cognitive functions, particularly attention and executive abilities, are linked to motor speech performance, though evidence quality varies and gaps remain.
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SDG:

Goal 3: Good health and well-being

Tags:

Health and wellbeing, Global

The impact of real-world evidence in implementing and optimizing Alzheimer's disease care

Elsevier,

Med, Volume 6, 9 May 2025

Real-world evidence can supplement clinical trial data to optimize Alzheimer’s disease care by aiding early patient identification and assessing drug effectiveness and safety in everyday use in diverse clinical settings/populations. This information helps inform clinical practice guidelines and supports the development of tools for timely diagnosis and personalized treatment strategies.
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SDG:

Goal 3: Good health and well-being

Tags:

Health and wellbeing, Global

The role of semaphorin 3A in the pathogenesis and progression of Alzheimer's disease and other aging-related diseases: A comprehensive review

Elsevier,

Pharmacological Research, Volume 215, May 2025

The article provides a comprehensive review of the role of semaphorin 3A (Sema3A) in the pathogenesis and progression of Alzheimer's disease and other aging-related diseases. It discusses the expression patterns and mechanisms of action of Sema3A in various age-related disorders, including its involvement in oxidative stress, inflammatory responses, apoptosis, and synaptic plasticity.
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SDG:

Goal 3: Good health and well-being

Tags:

Health and wellbeing; Health and population, Global

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