Elsevier,
American Journal of Clinical Nutrition, Volume 119, April 2024
This study aimed to assess the associations of both serum vitamin D status and supplementation with all-cause dementia, Alzheimer’s disease (AD), and vascular dementia (VD) incidence. It highlighted consistent associations between various facets of vitamin D and multivitamin intake, objectively measured vitamin D deficiency and insufficiency from blood samples, and 14-year dementia incidence in a study population aged 55 to 69 years at baseline. Subgroup analyses revealed effect modification by skin color with associations only observed in the non-brown/non-black skin color group and stronger effect estimates for vitamin D supplementation in younger compared to older study participants. Although results are encouraging and suggest a potential role for vitamin D supplementation in dementia prevention, particularly for those with vitamin D deficiency, caution is advised due to the observational nature of this study. RCTs with long follow-up periods are indispensable to establishing the efficacy of dementia prevention strategies.
Elsevier,
Advances in Nutrition, Volume 15, April 2024
This perspective provides a pioneering synthesis of clinical intervention trials examining the effects of fasting and caloric restriction on individuals suffering from neurodegenerative diseases, marking a comprehensive analysis on this topic.
Elsevier,
Heliyon, Volume 10, 30 April 2024
The study emphasizes practical application with a user-friendly website, empowering radiologists to predict class probabilities, track disease progression, and visualize patient images in both 2D and 3D formats, contributing significantly to the advancement of early AD detection.
Elsevier,
Frontiers in Neuroendocrinology, Volume 73, April 2024
This review discusses the multifaceted physiological functions of cholecystokinin (CCK), its potential neuroprotective effects in Alzheimer’s and Parkinson’s diseases, and its therapeutic implications, including its impact on memory, neurotransmitters, and neuroprotection mechanisms.
Elsevier,
Neuroscience, Volume 544, 19 April 2024
This study demonstrates that electroacupuncture (EA) improves learning and memory in the 5xFAD mouse model of Alzheimer's disease, likely by enhancing functional connectivity between the hippocampus and neocortex and reducing amyloid-β protein expression and deposition. These findings suggest that EA may positively impact resting-state brain activity and connectivity, contributing to cognitive and motor function improvements in AD.
Elsevier,
Brain Research, Volume 1829, 15 April 2024
Despite diagnostic challenges in differentiating lvPPA and nfvPPA, particularly in advanced cases, this study reveals divergent clinical courses and highlights the importance of assessing emotion processing capacity in dementia diagnosis and monitoring. Utilizing spatiotemporal LME modelling, the research provides valuable insights into the dynamic changes in brain atrophy and behavior, underscoring the need for ongoing evaluation of clinical requirements for patients and families over the disease course.
Elsevier,
Behavioural Brain Research, Volume 463, 12 April 2024
This article discusses the potential therapeutic strategy of enhancing mitophagy through rapamycin treatment to alleviate cognitive impairment in Alzheimer's disease by improving mitochondrial dysfunction and neuronal loss, suggesting a novel mechanism for the neuroprotective effects of rapamycin in AD.
Elsevier,
eClinicalMedicine, Volume 70, April 2024
This Article supports SDG 3 by arguing that people under community correction supervision (probation or parole) are a large population of individuals at risk of viral hepatitis, to whom little attention has thus far been paid. Targeting hepatitis testing and treatment services at this population would be feasible and effective in reducing hepatitis incidence.
