Global

This chapter supports SDG 3 by looking at how artificial intelligence (AI) can provide substantial improvements in all areas of healthcare from diagnostics to treatment.

Neurodegenerative diseases (NDD) such as Alzheimer's (AD) and Parkinson's disease (PD) are distinct clinical entities; however, the aggregation of key neuronal proteins, presumably leading to neuronal demise appears to represent a common mechanism. It has become evident that advanced glycation end products (AGEs) trigger the accumulation of such modified proteins, which eventually contributes to the pathological aspect of NDDs. Increased levels of AGEs are found in amyloid plaques in AD brains and in both advanced and early PD (incidental Lewy body disease). The molecular mechanisms by which AGE dependent modifications may modulate the susceptibility towards NDDs, however, remain enigmatic and it is unclear whether AGEs may serve as biomarker of NDD. This study detected differential associations between NDD, sex and oxidative stress markers.

This book chapter advances SDG3 Good Health and Wellbeing and SDG10 Reducing Inequalities by examining the research on wearable mechatronic devices for upper-limb amputees.