Background: Evidences of infectious pathogens in Alzheimer's disease (AD) brains may suggest a deteriorated innate immune system in AD pathophysiology.
Graphical summary of the methods used
Abnormal protein homeostasis (proteostasis), dysfunctional mitochondria, and aberrant redox signalling are often associated in neurodegenerative disorders, such as Huntington's (HD), Alzheimer's and Parkinson's diseases. It remains incompletely understood, however, how changes in redox signalling affect proteostasis mechanisms, including protein degradation pathways and unfolded protein responses (UPR). This article addresses this open question by investigating the interplay between redox signalling and proteostasis in a mouse model of HD, and by examining the in vivo effects of the mitochondria-targeted antioxidant MitoQ.
Psychological abuse within intimate relationships is linked to negative health outcomes among women and is frequently identified as more wounding than physical or sexual violence.
Background: Metabolic syndrome is characterised by a clustering of metabolic risk factors including abdominal obesity, raised triglycerides, lowered HDL cholesterol, hypertension and impaired glucose
Elsevier, Fire Safety Journal, Volume 110, December 2019
The International Association of Fire Safety Science (IAFSS) is comprised of members from some 40 countries.
Background: The population effects of armed conflict on non-combatant vulnerable populations are incompletely understood.
Elsevier, Current Opinion in Food Science, Volume 30, December 2019
Enteric viruses are an important food safety concern and have been associated with many foodborne disease outbreaks.
Elsevier, Journal of Neuroscience Methods, Volume 327, 1 November 2019
Background: Compared to previous neuropsychological investigations with standard paper-pen tests limited to test complex spatial learning and memory processes, 3-D virtual immersive technology might o
Neuropathic pain (NeuP) arises due to injury of the somatosensory nervous system and is both common and disabling, rendering an urgent need for non-addictive, effective new therapies.