This article provides an overview of the Age‐Friendly Emergency Department (AFED) model, a crucial component of a holistic age‐friendly health system with the potential to improve patient‐centered outcomes, reduce adverse events and hospitalizations, and enhance functional recovery. Age‐friendly healthcare is a comprehensive approach using the 4Ms framework—what matters, medications, mentation, and mobility—to ensure that healthcare settings are responsive to the needs of older patients.
In the Han Chinese populations on the Mongolian Plateau, the MTHFR G677A mutation is associated with increased homocysteine levels, which are linked to a higher risk of Alzheimer's disease. This genetic variant highlights the potential impact of folate metabolism on neurodegenerative conditions in this specific population.
This study shows how nurse-led health education improves dementia care by reducing behavioral problems and strengthening caregiver skills. By providing caregivers with lifelong learning and practical knowledge, it also advances quality education.
The review summarizes and discusses the potential role of psilocybin, a psychedelic compound, in altering mechanisms associated with major depression and neurodegenerative diseases. It examines the relationship between adult hippocampal neurogenesis, microglial activity, and their implications for the development of dementia, particularly in the context of major depression as a risk factor.
The impact of Alzheimer's disease (AD) and its related dementias is rapidly expanding, and its mitigation remains an urgent social and technical challenge.
Elsevier,

Annals of Emergency Medicine, Volume 83, May 2024

The emergency department (ED) poses unique challenges and risks to persons living with dementia. A longer ED length of stay is associated with the risk of death, delirium, and medication errors. This article seeks to determine whether ED length of stay differed by dementia status and trends in ED length of stay for persons living with dementia and whether persons living with dementia were at a higher risk for prolonged ED length of stay.
Repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) are two of the most used non-pharmacological interventions for Alzheimer's Disease (AD).

The study examined factors affecting the willingness of African-American and American Indian/Alaska Native communities to participate in Alzheimer's disease genetic and biomarker research, finding that these groups expressed less positive attitudes toward research compared to non-Hispanic White participants, which was related to their lower willingness to engage in preclinical Alzheimer's biomarker testing

The article discusses the potential relationship between alcohol consumptiond the development of Alzheimer's disease (AD), highlighting the role of the serotonergic system as a potential mediator. It synthesizes data from preclinical, clinical, and epidemiological studies to explore how alcohol-induced changes in serotonin function, neuroinflammation, and proteostasis may contribute to the onset and progression of AD

The article explores the role of microglia and neuronal subpopulations in Alzheimer's disease (AD) progression. It reveals that the microglia subpopulation Mic_PTPRG communicates with specific excitatory (ExNeu_PRKN_VIRMA) and inhibitory (InNeu_PRKN_VIRMA) neuronal subpopulations, leading to the upregulation of VIRMA, which inhibits mitophagy and causes neuronal death.

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