Real-world evidence can supplement clinical trial data to optimize Alzheimer’s disease care by aiding early patient identification and assessing drug effectiveness and safety in everyday use in diverse clinical settings/populations. This information helps inform clinical practice guidelines and supports the development of tools for timely diagnosis and personalized treatment strategies.
The article provides a comprehensive review of the role of semaphorin 3A (Sema3A) in the pathogenesis and progression of Alzheimer's disease and other aging-related diseases. It discusses the expression patterns and mechanisms of action of Sema3A in various age-related disorders, including its involvement in oxidative stress, inflammatory responses, apoptosis, and synaptic plasticity.
Empirical evidence on cognitive function and its association with demographic, socioeconomic, health and behavioural factors among older adults in rural Bangladesh.
The article discusses the role of gut dysbiosis, bacterial amyloids, and metabolic diseases in the development and progression of Alzheimer's disease (AD). It highlights the bidirectional relationship between the gut microbiome, inflammation, and metabolic disorders, and how these interconnected pathways contribute to neurodegeneration. The review explores potential therapeutic strategies targeting the gut-brain-metabolic axis to mitigate AD progression.
This systematic review examined the relationship between cognition and motor speech production in healthy older adults and those with mild cognitive impairment, analyzing 22 studies with 747 participants. Findings suggest that cognitive functions, particularly attention and executive abilities, are linked to motor speech performance, though evidence quality varies and gaps remain.
The article discusses advancements in using 3D models and human iPSC-derived microglia to study neurodevelopment and neurological disorders, highlighting their potential for understanding brain development, microglial functions, and disease mechanisms. It also explores various models, including organoids and xenotransplantation, and their applications in studying conditions like Alzheimer’s, Parkinson’s, and autism.
This chapter aligns with UN SDG goal 3, emphasizing the link between a healthy diet and disease prevention
The article examines the relationship between falls, chronic pain, and frailty among middle-aged and older adults in Yunnan Province, China, with a focus on ethnic minority populations.
Agriculture faces the increasing demands of a growing global population amid simultaneous challenges to soils from climate change and human-induced contamination.
Despite global progress, maternal mortality remains high, especially in sub-Saharan Africa, highlighting the urgent need for strong leadership, increased investment in well-trained midwives, and equitable, culturally sensitive maternity care to achieve the Sustainable Development Goal of reducing maternal deaths to less than 70 per 100,000 live births by 2030.
