Health and wellbeing

Health and well-being have a central role in the 17 Sustainable Development Goals (SDGs) endorsed by the United Nations, emphasizing the integral part they play in building a sustainable future. The third SDG explicitly calls for ensuring healthy lives and promoting well-being for all at all ages. This goal encompasses a wide range of health objectives, from reducing maternal and child mortality rates, combatting disease epidemics, to improving mental health and well-being. But beyond SDG 3, health is intrinsically linked with almost all the other goals.

When addressing SDG 1, which aims to end poverty, one cannot neglect the social determinants of health. Economic hardship often translates into poor nutrition, inadequate housing, and limited access to health care, leading to a vicious cycle of poverty and poor health. Similarly, achieving SDG 2, ending hunger, also contributes to better health through adequate nutrition, essential for physical and mental development and the prevention of various diseases.

Conversely, the repercussions of climate change, encapsulated in SDG 13, profoundly impact health. Rising global temperatures can lead to increased spread of infectious diseases, compromised food and water supplies, and increased frequency and intensity of extreme weather events, all posing severe health risks. Conversely, the promotion of good health can also mitigate climate change through the reduction of carbon-intensive lifestyles and adoption of healthier, more sustainable behaviors.

SDG 5, advocating for gender equality, also has substantial health implications. Ensuring women's access to sexual and reproductive health services not only improves their health outcomes, but also contributes to societal and economic development. Furthermore, achieving SDG 4, quality education, is also critical for health promotion. Education fosters health literacy, empowering individuals to make informed health decisions, hence improving overall community health.

Lastly, SDG 17 underlines the importance of partnerships for achieving these goals. Multi-sector collaboration is vital to integrate health considerations into all policies and practices. Stakeholders from various sectors, including health, education, agriculture, finance, and urban planning, need to align their efforts in creating sustainable environments that foster health and well-being.

Hence, the relationship between health, well-being, and the SDGs is reciprocal. Improving health and well-being helps in achieving sustainable development, and vice versa. In this context, health and well-being are not just outcomes but are also powerful enablers of sustainable development. For the world to truly thrive, it must recognize and act upon these interconnections.

This content aligns with Goal 3: Good Health and Wellbeing by discussing HIV cell and host tropism, functions of structural, regulatory, and auxiliary proteins and provides a general overview of pathogenesis, vaccine development, and treatments.
Elsevier,

Clinical Immunology (Sixth Edition)
Principles and Practice
2023, Pages 525-541

This content aligns with Goal 3: Good Health and Wellbeing by highlighting the interactions of the Human immunodeficiency virus (HIV)-1 with the immune system.
Elsevier,

Health Information Exchange (Second Edition)
Navigating and Managing a Network of Health Information Systems
2023, Pages 603-619

This content aligns with Goal 3: Good Health and Wellbeing by providing examples of how low- and middle-income countries (LMIC) can adopt HIE principles in one health program to gain essential implementation experience that can inform scale-up, and adoption of similar systematic approaches in the wider national health system.
Elsevier,

Clinical Immunology (Sixth Edition)

Principles and Practice

2023, Pages 972-982

Typical histological findings of autoimmune hepatitis showing marked lymphoplasmacellular infiltration of the portal tract with interface hepatitis.
This content supports the SDG Goal 3: Good health and well-being by Typical histological findings of autoimmune hepatitis showing marked lymphoplasmacellular infiltration of the portal tract with interface hepatitis. the main characteristics of AIH, PBC, and PSC, with particular interest for the clinical manifestations, pathogenesis, autoantibodies, and therapeutic options.
Elsevier,

Clinical Immunology (Sixth Edition)
Principles and Practice
2023, Pages 573-585

This content links with Goal 3: Good health and well-being and Goal 10: Reduced Inequalities by focusing on the role of eosinophils in health and disease, including novel therapeutic approaches and their contribution to our understanding of the role that eosinophils play in homeostasis and pathogenesis.
This content links with Goal 3: Good health and well-being and Goal 10: Reduced Inequalities by providing information about esophageal squamous cell carcinoma (ESCC) and the upper aerodigestive microbiomes role in carcinogenesis and outcomes.
Elsevier,

Viral, Parasitic, Bacterial, and Fungal Infections
Antimicrobial, Host Defense, and Therapeutic Strategies
2023, Pages 757-770

This content aligns with Goal 3: Good Health and Wellbeing by discussing the use of phytomedicines and phytotherapy as economical and safe alternatives to other treatments in infectious diseases such as HIV, malaria, dengue, hepatitis, and COVID-19.
Elsevier,

Clinical Immunology (Sixth Edition)
Principles and Practice
2023, Pages 832-842

This content links with Goal 3: Good health and well-being and Goal 10: Reduced Inequalities by advancing understanding of MG pathophysiology to improve current therapies and contribute to the development of novel, MG-specific therapeutics.
Elsevier,

Oncogenic Viruses

Volume 2: Medical Applications of Viral Oncology Research

2023, Pages 253-266

Oncovirus cancer is a group of more than 100 different diseases. It can develop almost anywhere in the body. Initiation of cancer largely due to genetic changes interferes with the normal process, leading to uncontrolled cell growth. This huge cell mass transforms into a tumor, which can be benign or cancerous and can be malignant, which can grow and spread to other parts of the body. Whereas some types of cancers are nontumorous like leukemia, cancers like lymphoma and myeloma are tumorous. Apart from genetic mutations and other environmental factors such as chemical changes and change in lifestyle, approximately 12% of human cancers occur due to viruses and they are known as oncoviruses. A huge group of people harbors at least one of these oncoviruses, but few go on to develop into cancer. The path from oncovirus infection to the onset of cancer in humans involves a complex process. The viral factors and host interaction create a favorable microenvironment for oncogenesis. At present, seven human oncoviruses are known: Epstein–Barr virus (EBV), human papillomavirus (HPV), Hepatitis B and C viruses (HBV and HCV), human T-cell lymphotropic virus-1 (HTLV-1), human herpesvirus-8 (HHV-8), and Merkel cell polyomavirus (MCPyV). As the first human oncovirus, EBV was first detected in Burkitt lymphoma cells by electron microscopy in 1964. Since then work in oncovirology has been carried out on a large scale to understand the host–virus pathogenesis. Globally, around 20% of all cancers are caused by infectious agents and 12% are caused due to the oncoviruses, and of these, approximately 80% of viral cancers occur in the developing nations. With the help of the existing biochemical techniques such as genomics and proteomics, the identification of virus and their role in the cancer pathogenesis could be investigated, but still knowledge about their microenvironment and interactions is lacking. Current computational techniques support the deep mining of information, and knowledge modeling with preexisting data helps in understanding the sequence-to-sequence mapping followed by structure elucidation, which brings more curated data into the picture. Bioinformatics, cheminformatics, and amalgamation of artificial intelligence play an important role in research in the field of oncovirology. The large datasets obtained from multiple biochemical experiments contain gigabytes of data related to the sequence, structure, and interactions of oncoviruses. Techniques such as computational genomics, computational proteomics, interactomics, sequence analysis, structure modeling, systems biology, protein modeling, and computer-aided drug design have significantly contributed to making research in this field cost-effective.

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