Global

The study demonstrates that the peptide PHDP5, which inhibits dynamin-MT interaction, can rescue impaired endocytosis and synaptic transmission caused by tau in presynaptic terminals. When administered intranasally to Alzheimer's disease (AD) model mice, PHDP5 significantly improved learning and memory, suggesting its potential as a candidate for human AD therapy.
Despite significant investment, effective treatments for Alzheimer's disease (AD) have been elusive, necessitating improved quality and reproducibility of foundational laboratory evidence; to address this, AD-SOLES, an integrated workflow of automated tools and a publicly accessible interactive dashboard, has been developed to collect, curate, and visualize in vivo experimental evidence, enhancing evidence synthesis, tracking reporting quality, and aiding researchers in locating relevant data.
Nurse practitioners and other health care providers can play a crucial role in implementing chronic disease management strategies and educating patients who are at risk for AD among African Americans and Hispanics.
This study evaluated the behavioral, physiological, and molecular effects of social isolation (SI) in adult zebrafish, and whether the animals recover such changes after their reintroduction to the social environment. The results show that SI altered social behaviors, neural activity, and serotonergic and dopaminergic signaling in zebrafish, but these changes were reversed after the animals were reintroduced to a social context for 6 days.

More than 1100 people came together virtually on 18 June 2024 for the tenth edition of the RELX SDG Inspiration Day: "In the Age of AI: Information to Advance the UN Sustainable Development Goals (SDGs)." The annual online event brings together thought leaders, corporate representatives, students, investors, governments, and NGOs to explore pressing issues, gain practical insight, and inspire action on the United Nations Sustainable Development Goals (SDGs).

Elsevier,

Archives of Gerontology and Geriatrics Plus, Volume 1, Issue 4, December 2024, 100072

This study reveals that the estimation of lipids and carotenoid levels could support the early diagnosis or help to understand the pathophysiology of Alzheimer's Disease.

Elsevier,

Global Ecology and Conservation, Volume 52, August 2024

This paper highlights the importance for conservation biologists and on-the-ground practitioners to engage more with local pastoralists to tackle the complex and infrequently described conflicts on how best to implement protective policies.
Image of a microscope in a laboratory

Recognising our customers' exceptional work to achieve the UN Sustainable Development Goals.

Elsevier,

Archives of Gerontology and Geriatrics, Volume 123, August 2024

Interaction of human and socially assistive robot can have applicability in actual settings, and adoption to function in human environment for Alzheimer's disease. This review revealed that there are still several technical challenges that must be addressed in future advancements before being integrated in real life of individuals with Alzheimer's disease. The results will help move towards the establishment of best practices for the development of human and socially assistive robot interaction for Alzheimer's disease and, in turn, help enhance the experience of people suffering from this disease.
Dementia is a global leading cause of disability and death among older adults, and there is a need to carefully evaluate existing evidence on related risk factors to guide future research. This review summarized and evaluated the most updated evidence on associations of various magnesium forms (supplements, dietary intake, and biomarkers) with cognitive outcomes in adults, based on evidence from randomized controlled trials and cohort studies.

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