Global

Introduction: Estrogen receptors (ER) (ERα, ERβ) and aromatase (key enzyme for estrogen synthesis) are expressed in most human NSCLCs. High intratumoral estrogen levels and elevated aromatase expression in NSCLC predict poor outcome. This open-label, phase 1b, single-center study evaluated the safety and tolerability of escalating doses of the aromatase inhibitor, exemestane, in combination with carboplatin and pemetrexed in postmenopausal women with stage IV nonsquamous NSCLC.
Elsevier, Progress in Disaster Science, Volume 10, April 2021
The COVID-19 pandemic has uncovered and intensified existing societal inequalities. People on the move and residents of urban slums and informal settlements are among some of the most affected groups in the Global South. Given the current living conditions of migrants, the WHO guidelines on how to prevent COVID-19 (such as handwashing, physical distancing and working from home) are challenging to nearly impossible in informal settlements.
" This Comment article supports SDG 3 and 10 by proposing that future studies exploring the link between racism and health inequalities are designed with more theoretically informed research questions, whose findings can more readily help tackle existing problems. Suggested areas for further research include the impact of neighourhood desegregation, increased racial diversity in labour markets, and reduced mass incarceration in diminishing racial health inequalities.
Elsevier,

The Lancet Global Health, Volume 9, April 2021

This Comment article supports SDGs 3, 10, and 17 by highlighting the need for full inclusivity and representation, and the involvement of a diverse range of stakeholders and voices, in order to successfully design solutions to global health problems and to reform the systems that are exacerbating global health inequities.

Data-driven digital health technologies have the power to transform health care. If these tools could be sustainably delivered at scale, they might have the potential to provide everyone, everywhere, with equitable access to expert-level care, narrowing the global health and wellbeing gap. Conversely, it is highly possible that these transformative technologies could exacerbate existing health-care inequalities instead.

Background: Increasing access to hepatitis C virus (HCV) care and treatment will require simplified service delivery models. We aimed to evaluate the effects of decentralisation and integration of testing, care, and treatment with harm-reduction and other services, and task-shifting to non-specialists on outcomes across the HCV care continuum.
This chapter supports SDGs 3, 16 by exploring the challenges confronting internally displaced persons and refugee children.

Compared to other climate regions of the world, Mediterranean regions are likely to experience more severe effects of climate change as rainfall decreases and temperatures increase. Global climate change models predict a reduction in rainfall and rise in the temperature of rivers in South Africa's Cape Fold Ecoregion (CFE) – a Mediterranean region in the south-west corner of the country.

This study identified, for the first time, determinants of low Symphysis–Fundal Height (SFH) in the context of multiple infections, nutrient deficiencies, and inflammation in a marginalized community of pregnant indigenous women and recommends the use of low SFH as a screening tool in remote settings for the identification of high-risk pregnancies is a first step to improve maternal and fetal health
Earth Day is widely recognised as the largest secular observance in the world, marked by more than a billion people every year as a day of action to change human behaviour and provoke policy changes. This day recognises and celebrates the Earth and its ecosystems as our home and highlights the need to protect earth to enhance people’s livelihoods, counteract climate change, and stop the collapse of biodiversity. To raise awareness of Earth Day 2021, Elsevier presents a curated list of free access journal articles and book chapters in support of this year's theme - Restore our Earth.

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