Global

This article outlines a theory of goodness, coupled with some of its practical implications for impact-making, governance and lives more generally. The theory proposes that goodness consists of positive feelings and whatever promotes them, such as the joy of a meaningful conversation or the satisfaction of eating food, for instance. Although it is a version of ethical hedonism, the theory is also called welfarism since it allocates a central role to affect and since affect is central to some prevalent measures of 'subjective wellbeing'.

This paper reviews and compares four leading healthy diet metrics: GDQS, GDR score, MDD-W, and Nova UPF score, for their accuracy, ease of use, and global applicability in monitoring dietary quality. The findings highlight that the Minimum Dietary Diversity for Women (MDD-W) offers the strongest predictive accuracy for nutrient adequacy using a simple, scalable method, while also emphasizing the need for further research on metrics assessing moderation and cross-country comparability.

Drivers of health disparities in rheumatology are numerous and complex, existing within and between populations. These impact access to advanced therapies, specialized services, and core components of care.

International Day of Human Space Flight 2026: A Tribute to Exploration, Unity, and Progress

International Day of Sport for Development and Peace 2026: Sport as a Bridge for Inclusion and Unity

Earth Day 2025

22nd April is Earth Day, an annual, global movement to raise awareness and promote environmental protection. The theme for Earth Day 2025 is OUR POWER, OUR PLANET, inviting everyone around the globe to unite behind renewable energy, and to triple the global generation of clean electricity by 2030. To mark the event Elsevier has curated a free to access Special Collection featuring the latest research articles and book chapters to advance knowledge.

This perspective highlights the challenges and opportunities of implementing people-centered multi-hazard early warning systems in the Global South, emphasizing the need for localized, inclusive approaches that address vulnerability and the complex interrelationships of hazards, to bridge the gap between global ambitions and operational realities.

This study demonstrated that physical exercise pretreatment improves recognition memory and enhances structural synaptic plasticity in the hippocampus of Alzheimer’s disease (AD) rats, primarily through the activation of hippocampal TREM2. Blocking TREM2 diminished these neuroprotective effects, indicating that exercise mitigates synaptic injury and cognitive decline in AD via a TREM2-dependent mechanism.
This study identifies two CSF proteomic panels that accurately stage Alzheimer’s pathology, outperform current biomarkers, and predict dementia progression over 10 years, enhancing diagnosis and clinical trial stratification.
The article describes the discovery and development of compound 8e, a selective and reversible butyrylcholinesterase (BuChE) inhibitor, as a potential therapeutic agent for treating Alzheimer's disease (AD). Compound 8e exhibited favorable blood-brain barrier permeability, good drug-likeness properties, and pronounced neuroprotective efficacy in various AD models, including zebrafish, scopolamine-induced mice, and APP/PS1 transgenic mice.

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