In this study, a novel reporter substrate named C8CF3-coumarin was synthesized and then characterized, an assay protocol was developed to identify small molecular activators of PLCγ enzymes, and a proof-of-principle high throughput screen was conducted using PLCγ2 and the LOPAC1280 library. These studies showed that C8CF3-coumarin could indeed monitor PLCγ enzyme activity and identify potential small molecule activators from a screen. The identification of such small molecule PLCγ2 activators would be of great utility to the Alzheimer's disease research community by serving as both chemical probes to study the modulation of PLCγ2 and as potential therapeutic agents.
Elsevier,
Promoting Desired Lifestyles Among Adults with Severe Autism and Intellectual Disabilities
Person Centered Applications of Behavior Analysis
2023, Pages 275-293
This content aligns with Goal 3: Good Health and Wellbeing and Goal 10: Reduced Inequalities by stressing the importance of human service staff treating adults with severe disabilities with dignity.
Elsevier,
Promoting Desired Lifestyles Among Adults with Severe Autism and Intellectual Disabilities
Person Centered Applications of Behavior Analysis
2023, Pages 139-163
This content aligns with Goal 3: Good Health and Wellbeing and Goal 10: Reduced Inequalities by providing specific aspects of agency supports and services in accordance with identified preferences of adults with severe disabilities.
This study evaluates climate change impacts on U.S. agriculture using process-based and econometric models.
Elsevier,
Promoting Desired Lifestyles Among Adults with Severe Autism and Intellectual Disabilities
Person Centered Applications of Behavior Analysis
2023, Pages 3-14
This content aligns with Goal 3: Good Health and Wellbeing and Goal 10: Reduced Inequalities by discussing the importance of promoting desired lifestyles among adults with severe autism and intellectual disabilities, and how the operations of many adult service agencies fail to promote individually desired lifestyles.
To mark the 50th Anniversary of World Environment Day on 5 June 2023, Elsevier proudly presents a curated list of publicly available journal articles and book chapters in support of this year's theme “Solutions to Plastics Pollution”. Please share and download.
This content aligns with Goal 3: Good Health and Wellbeing by providing an overview of the human immunodeficiency virus
This article advances SDG # 13 and 9 by making recommendations for unlocking the mechanism by which the plastics industry is tied to the fossil fuel-based economies.
This article highlights the risks of a polluted environment on our health, especially reproductive health and female fertility.
This article advances SDG # 13, 14, and 15 by arguing that ecosystem integrity is neglected but important for climate adaptation goals, and shows how linking ecosystem integrity to climate, biodiversity and sustainable development goals is crucial for optimal outcomes.
