Neurological disorders affect approximately one billion people worldwide, with significant disability and mortality impacts, and this review explores how Heparan sulfate proteoglycans (HSPGs) promote Tau fibril formation and tangles in Alzheimer's disease, and the potential role of tunnelling nanotubes (TNTs) in the intercellular transport of Tau and Amyloid β proteins, suggesting that HSPGs may influence TNT formation in neurodegenerative conditions.
This study identified key biochemical pathways and protein changes in the Alzheimer's disease (AD) human hippocampus, revealing increased expression of proteins VGF, GFAP, HSPB1, and APP, with UBC being most centrally involved, and highlighted the roles of four hub proteins (CD44, APP, ITGB2, APOE) linked to amyloid plaques and two (RPL24, RPS23) to neurofibrillary tangles, along with the impact of modified proteins on immune activation and synaptic disruption, uncovering potential therapeutic targets involving specific proteins, microRNAs, and transcription factors.
This study presents an optimized method for isolating specific neuronal and glial cell populations and extracellular vesicles (EVs) from postmortem Alzheimer's disease (AD) cortical samples, demonstrating the feasibility of using a single cryopreserved brain sample to obtain RNA-seq and protein-level data, thereby enhancing understanding of neuron/glial interactions and disease progression.
This article summarizes current biomarkers, available treatments, and future therapeutic approaches for Alzheimer's disease, discussing drug targets like Amyloid β, Tau Protein, and various other mechanisms. Additionally, it highlights the historical use of Estradiol, outcomes of trials with antioxidants and omega-3 fatty acids, and ongoing clinical trials, providing a comprehensive overview of the evolving landscape in AD research and treatment.
Elsevier's 2024 Gender Equality Study Reveals 20 Years Of Progress, But Challenges Remain For Women in Research And Innovation
Until now, the absence of data on global building floorspace has impeded the measurement of building carbon intensity (carbon emissions per floorspace) and the identification of ways to achieve carbon neutrality for buildings. For this study, we develop a global building stock model (GLOBUS) to fill that data gap.
This Article supports SDG3 by evaluating sex and gender disparities in terms of risk factors, treatment uptake/completion, and virological outcomes for hepatitis C, finding differences between men and women in, for example, exposure to different risk factors and likelihood of commencing treatment. More attention is needed in research to these disparities and how they could be addressed
This article links to the United Nations Sustainable Development Goals (SDGs) by addressing Goal 3 (Good Health and Well-Being) and Goal 13 (Climate Action), as it highlights the significant greenhouse gas emissions associated with radiotherapy, a critical component of cancer treatment. By proposing strategies to reduce the environmental impact of oncology care through sustainable practices and treatment modifications, the study emphasizes the importance of integrating health care with climate action efforts to promote both patient well-being and environmental sustainability.
The article underscores the need to reform the health claim evaluation process for foods by adopting a holistic approach that integrates multiple nutritional and contaminant attributes. This approach should involve cumulative risk assessment and risk-benefit analysis to provide a more accurate picture of food's health impacts. Such reforms align with global sustainability goals and would help address the complexities of modern food systems, ultimately promoting better health outcomes and environmental stewardship.
In this study, the authors analyse alternative pembrolizumab administration strategies that might have environmental advantages over the current dosing and compounding paradigms (improved environmental sustainability without sacrificing clinical outcomes)
