Elsevier, iScience, Volume 28, 15 August 2025
Adsorption technology is an essential part of modern water treatment. However, only a handful of adsorbent materials are used industrially, which is in striking contrast with the exponentially increasing scientific publishing activity. In this perspective, the aim is to discuss the global progress on the adsorbent materials development by using the reported adsorption capacities as a simple probe. An automated text analyzer employing a large language model was used to extract adsorption data.
Elsevier,
Journal of Pharmacology and Experimental Therapeutics, Volume 392, August 2025
This review discusses the dual role of amyloid-beta (Aβ) in Alzheimer's disease (AD). While Aβ accumulation is a hallmark of AD pathology, soluble Aβ also plays a neuroprotective role in regulating synaptic plasticity and memory. The review explores the potential of anti-Aβ immunotherapy as a treatment strategy, highlighting the need to balance targeting toxic Aβ species while preserving the physiological functions of Aβ.`
Elsevier,
Pharmacological Research, Volume 218, August 2025
This article describes the discovery and characterization of FJMU1887, a novel brain-penetrant small-molecule inhibitor of Galectin-3 (Gal-3) identified through an AI-driven drug discovery platform. FJMU1887 demonstrated potent anti-inflammatory effects, reduced Aβ pathology, and improved cognitive function in Alzheimer's disease mouse models, highlighting its therapeutic potential for the treatment of Alzheimer's disease.
Elsevier,
Pharmacological Research, Volume 218, August 2025
The article provides a comprehensive overview of the role of the endogenous detoxification system in the pathogenesis of age-related neurodegenerative diseases, particularly Alzheimer's disease (AD) and Parkinson's disease (PD). It highlights epidemiological evidence linking environmental toxicant exposure to the onset and progression of these diseases, and discusses how dysfunction of detoxification pathways, including enzymes and transporters, can exacerbate neurodegenerative processes. The article also explores the potential of targeting nuclear receptor signaling pathways, such as the pregnane X receptor (PXR), as a promising therapeutic strategy to restore detoxification capacity and modify disease trajectories.
Elsevier,
Brain Research Bulletin, Volume 228, August 2025
This study investigated how repetitive transcranial magnetic stimulation (rTMS) combined with cognitive training affects functional connectivity in both gray matter and white matter in patients with mild to moderate Alzheimer’s disease. Results showed that rTMS modulated activity in key brain regions, particularly within the limbic system, with changes in white matter connectivity correlating with cognitive improvements.
Elsevier,
Journal of Prevention of Alzheimer's Disease, Volume 12, 1 August 2025
The article estimates the value-based price of a blood test for Alzheimer's disease pathology, finding it would be $290-$1150 in primary care and $450-$1950 in specialty care, projecting substantial cost savings.
Elsevier,
Journal of Prevention of Alzheimer's Disease, Volume 12, 1 August 2025
The study found that long-duration and high-intensity walking were associated with reduced amyloid-beta accumulation over 4 years, with the greatest benefits seen in those who started walking earlier in life. However, walking activity was not linked to changes in tau deposition, neurodegeneration, or white matter hyperintensities.
Elsevier, Journal of Allergy and Clinical Immunology, Volume 156, August 2025
This study investigated how host genetics and early-life environmental exposures influence the infant gut microbiota during the first year of life and its association with childhood asthma and allergic diseases by age 5 years. The researchers found that specific gut microbial changes and network clusters were associated with increased or decreased risk of asthma, wheeze, atopic dermatitis, and food/inhalant sensitization, with some associations being sex-specific
Elsevier, Journal of Allergy and Clinical Immunology, Volume 156, August 2025
This study examined how air pollution exposure affects asthma treatment effectiveness in Black children by reanalyzing data from the AsthmaNet BARD clinical trial. The researchers found that children with lower nitrogen dioxide (NO2) exposure had significantly better lung function improvements when treated with high-dose inhaled corticosteroids plus long-acting ?-agonists compared to children with higher NO2 exposure. The findings suggest that residential air pollution exposure, particularly NO2, may reduce the effectiveness of standard asthma treatments in Black children, highlighting the need to consider environmental factors in asthma management strategies.
