Articles

The authors highlight how the Indigenous view of health has always understood the interconnects among people, animals and the environment, which is the foundation of what is now a western concept called “One Health”. They call for Indigenous understandings of the connection to be embedded into One Health approaches. They propose that future studies utilise local Indigenous seasonal calendars, which are often based on environmental cues, to help understand the seasonal effects of zoonoses.

This perspective highlights the challenges and opportunities of implementing people-centered multi-hazard early warning systems in the Global South, emphasizing the need for localized, inclusive approaches that address vulnerability and the complex interrelationships of hazards, to bridge the gap between global ambitions and operational realities.

The article describes the discovery and development of compound 8e, a selective and reversible butyrylcholinesterase (BuChE) inhibitor, as a potential therapeutic agent for treating Alzheimer's disease (AD). Compound 8e exhibited favorable blood-brain barrier permeability, good drug-likeness properties, and pronounced neuroprotective efficacy in various AD models, including zebrafish, scopolamine-induced mice, and APP/PS1 transgenic mice.

This study provides evidence of distinct alterations in resting-state functional connectivity in individuals with amnestic mild cognitive impairment (aMCI) and late-life depression (LLD), underscoring region-specific vulnerabilities that may contribute to cognitive decline and depressive symptomatology in older adults.