Articles

Elsevier, Neuron, Volume 101, 20 March 2019
Altered synaptic structure and function is a major hallmark of fragile X syndrome (FXS), autism spectrum disorders (ASDs), and other intellectual disabilities (IDs), which are therefore classified as synaptopathies. FXS and ASDs, while clinically and genetically distinct, share significant comorbidity, suggesting that there may be a common molecular and/or cellular basis, presumably at the synapse.
Elsevier, Neuron, Volume 101, 6 March 2019
Alzheimer's disease (AD) is considered a polygenic disorder. This view is clouded, however, by lingering uncertainty over how to treat the quasi “monogenic” role of apolipoprotein E (APOE). The APOE4 allele is not only the strongest genetic risk factor for AD, it also affects risk for cardiovascular disease, stroke, and other neurodegenerative disorders. This review, based mostly on data from human studies, ranges across a variety of APOE-related pathologies, touching on evolutionary genetics and risk mitigation by ethnicity and sex.
Elsevier, She Ji, Volume 5, Spring 2019
There is a metabolic rift running through our economy and culture, and it is distracting our attention from care for the biosphere. To heal this rift, the diverse groups of people that make up humankind need a shared purpose that everyone can relate to and support. A strong candidate for that shared purpose is care for the bioregion—bioregioning—as an activity that creates value.
Elsevier, Renewable and Sustainable Energy Reviews, Volume 101, March 2019
Research into alternative renewable energy generation is a priority, due to the ever-increasing concern of climate change. Microbial fuel cells (MFCs) are one potential avenue to be explored, as a partial solution towards combating the over-reliance on fossil fuel based electricity. Limitations have slowed the advancement of MFC development, including low power generation, expensive electrode materials and the inability to scale up MFCs to industrially relevant capacities. However, utilisation of new advanced electrode-materials (i.e.
Elsevier, Annals of Emergency Medicine, Volume 73, March 2019
Study objective: We estimate emergency department (ED) use differences across Medicare enrollees of different race/ethnicity who are residing in the same zip codes. Methods: In this retrospective cohort study, we stratified all Medicare fee-for-service beneficiaries aged 66 years and older (2006 to 2012) by residence zip code and identified zip codes with racial/ethnic diversity, defined as containing at least 1 enrollee from each of 3 racial/ethnic groups: Hispanics, (non-Hispanic) blacks, and (non-Hispanic) whites.
Elsevier,

Elsevier Connect, February 26, 2019

This special issue of The Lancet is dedicated to advancing SDG 5 (gender equality) with its focus on gender equity in science, medicine and global health.
Elsevier, Reliability Engineering and System Safety, Volume 182, February 2019
It has been estimated that European customers visit community pharmacies to access essential primary healthcare around 46 million times every day. Studies of dispensing error rates in community pharmacies have reported error rates of between 0.08% and 3.3% per item dispensed. While severe cases of dispensing inaccuracies often garner a high level of media coverage, less significant errors are also causing inefficiencies in primary healthcare delivery.
Elsevier, Trends in Ecology and Evolution, Volume 34, February 2019
The emerging insects-as-food industry is increasingly promoted as a sustainable alternative to other animal protein production systems. However, the exact nature of its environmental benefits are uncertain because of the overwhelming lack of knowledge concerning almost every aspect of production: from suitable species, their housing and feed requirements, and potential for accidental release.
Elsevier, Trends in Ecology and Evolution, Volume 34, February 2019
There is worldwide concern about the environmental costs of conventional intensification of agriculture. Growing evidence suggests that ecological intensification of mainstream farming can safeguard food production, with accompanying environmental benefits; however, the approach is rarely adopted by farmers. Our review of the evidence for replacing external inputs with ecosystem services shows that scientists tend to focus on processes (e.g., pollination) rather than outcomes (e.g., profits), and express benefits at spatio-temporal scales that are not always relevant to farmers.

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