Correspondence on the factors behind low COVID-19 immunisation coverage among marginalised communities in Latin America and the Caribbean, in the context of SDGs 3 and 10, highlighting the need to consider the specific circumstances of Indigenous communities in the development of national COVID-19 immunisation campaigns.
Niemann-Pick type C (NPC) disease, a lysosomal storage disorder caused by defective NPC1/NPC2 function, results in the accumulation of cholesterol and glycosphingolipids in lysosomes of affected organs, such as liver and brain. Moreover, increase of mitochondrial cholesterol (mchol) content and impaired mitochondrial function and GSH depletion contribute to NPC disease. However, the underlying mechanism of mchol accumulation in NPC disease remains unknown. As STARD1 is crucial in intramitochondrial cholesterol trafficking and acid ceramidase (ACDase) has been shown to regulate STARD1, we explored the functional relationship between ACDase and STARD1 in NPC disease.
There is an urgent need to endorse a protective therapy for ALS patients. Possible treatments might be based on the underlying molecular pathophysiology. Some of the ALS dysregulated routes could be targeted by a single hit in NRF2. NRF2 emerged as a druggable target in preclinical and clinical trials for ALS.
Given their carbon emissions, pharmaceutical companies must intensify their efforts and play an active role in addressing climate change.
This study demonstrates that systems science provides positive implementation approaches to design and translates nutrition behaviors and knowledge into practice.
This exploratory study examines parental opinions about receiving climate change information at their child's checkup.
This exploratory study examines parental opinions about receiving climate change information at their child's checkup.
Mitochondrial myopathy (MM) encompasses a clinical heterogenous group of patients that can be difficult to diagnose. This article investigates whether changes in plasma lactate concentration during a 6-minute submaximal handgrip test (6MHGT) and a 20-minute post-exercise recovery period can be used as a diagnostic test for MM.
This Editorial highlights the relationship between climate change, fires, floods and infectious diseases.
The Sustainable Development Goals call for countries to reduce premature mortality from non-communicable diseases through mental health promotion, prevention, and treatment (Target 3.5) and for health services to be made universally available (Target 3.8). This paper is part of a broad, global effort to build the capacity of health systems in high-need settings to expand access to mental health services by integrating those services into primary care. In South Africa, nurses are at the heart of this integration effort, and our goal was to learn how best to support nurses to integrate mental health services into their work.
