MiRNA mouse models are emerging tools to study the protective and/or deleterious effects of miRNAs in human diseases. In the current study, miR-455-3p TG and KO models were successfully generated by using pronuclear injection of miR-455-3p transgene to mouse embryo and CRISPER/Cas9 knockout techniques.
"A diverse range of biochemical and cellular assays are used by medicinal chemists to guide compound optimization. The data collected from these assays influence decisions taken on structure-activity relationship (SAR) campaigns. Therefore, it is paramount that medicinal chemists have a solid understanding of the strengths and limitations of each assay being used to characterize synthesized analogs. This Perspective Article takes a look at assays relevant to Gaucher, Pompei, Wolman, and Fabry disease, Duchenne muscular dystrophy, and Cystic Fibrosis."
This study explores the pathways from a nutrition-sensitive agriculture intervention to improved diets of women and young children. It also tests theoretical agriculture-to-nutrition pathways by comparing the authors' documented pathways with the pathways from the widely used TANDI (Tackling the Agriculture–Nutrition Disconnect in India) framework.
The high rate of SARS-CoV-2 infection poses a serious threat to public health. Previous studies have suggested that SARS-CoV-2 can infect human ovary, the core organ of the female reproductive system. However, it remains unclear which type of ovarian cells are easily infected by SARS-CoV-2 and whether ovarian infectivity differs from puberty to menopause.
The authors' goals of this study (associated with 13 dietary patterns or scenarios) are to assess 1) to what extent current food utilization in Indonesia (2 patterns) provides for meeting health and nutrition targets and how its GHGe (greenhouse gas emissions) and water footprints compare to global targets; and 2) how alternative dietary scenarios, optimized to meet nutrient needs at the lowest possible cost (7 scenarios) or designed to be more healthy and environmentally friendly (4 scenarios), compare to current food patterns for nutrient content, agricultural contributions to climate change, and freshwater conservation, as well as cost.
Elsevier,

The Lancet Public Health, Volume 6, November 2021

A Viewpoint on Europe's response to climate change, in the context of SDGs 12, 13, and 17, focusing specifically on the use of region-specific indicators to address the main challenges and opportunities of Europe's response in the context of public and planetary health.
Elsevier, International Journal of Intercultural Relations, Volume 85, November 2021
This article examines the role of empathy for outgroup helping, collective action and political activism among youth in Northern Ireland, a setting of protracted conflict.
In this article, we pursue the automatic detection of fake news reporting on the Syrian war using machine learning and meta-learning.
Introduction: Air pollution may play an important role in the development of lung cancer in people who have never smoked, especially among East Asian women.

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