Global

Graphical abstract
Proteasome function is impaired in Alzheimer's disease (AD). Proteasome activation is followed by a decrease in amyloid-beta (Aβ) load. A reduced amount of Aβ correlates with significantly improved behavior and frailty level. Proteasome activation represents a promising intervention for alleviating AD pathology.
In this first episode of the “World We Want” podcast series, RELX’s Global Head of Corporate Responsibility, Dr Márcia Balisciano, talks to Georg Kell about leadership.

This is a special issue on food systems for children and adolescents with research on food marketing, nutrition and sustaining healthy diets and food supply chains. It brings together research advancing SDGs 2, zero hunger, SDG 3, good health and wellbeing and SDG 12, responsible production and consumption. 

This Article supports SDG 3 by summarising global, regional, and national estimates of the burden of tracheal, bronchus, and lung cancer and larynx cancer and their attributable risks from 1990 to 2019, and highlighting the importance of preventive measures such as smoking control interventions, air quality management programmes focused on major air pollution sources, and widespread access to clean energy.
Graphical abstract of article
Laughter therapy is a universal non-pharmacologic approach to reduce stress and anxiety. Laughter therapy can be used during COVID-19 pandemic as a useful supplementary therapy to reduce the mental health burden.
Women represent ⅔ of the cases of Alzheimer's disease (AD). Current research has focused on differential risks to explain higher rates of AD in women. However, factors that reduce risk for AD, like cognitive/brain reserve, are less well explored. We asked: what is known about sex and gender differences in how reserve mitigates risk for AD?
Using event-related potentials (ERPs) might help identify early neural changes indicative of future cognitive decline, offering an accessible and affordable alternative to other neuroimaging methods
A good study that looked at the mathematical method to evaluate the drug resistant of virus emergence using HIV/AIDS treatment cases.
This chapter advances SDG 6, 7, and 11 by examining the role of resource recovery technologies in reducing the demand of fossil fuels and conventional fossil-based mineral fertilizers, including through the production of sustainable biofuels such as hydrogen, syngas, and bio-oil.
Nuclear erythroid 2-related factor 2 (Nrf2)/Kelch-like ECH-associated protein 1 (Keap1) signalling pathway and its downstream target effects.
Imbalances in redox homeostasis can result in oxidative stress, which is implicated in various pathological conditions including the fatal neuromuscular disease Duchenne Muscular Dystrophy (DMD). DMD is a complicated disease, with many druggable targets at the cellular and molecular level including calcium-mediated muscle degeneration; mitochondrial dysfunction; oxidative stress; inflammation; insufficient muscle regeneration and dysregulated protein and organelle maintenance. Previous investigative therapeutics tended to isolate and focus on just one of these targets and, consequently, therapeutic activity has been limited. Nuclear erythroid 2-related factor 2 (Nrf2) is a transcription factor that upregulates many cytoprotective gene products in response to oxidants and other toxic stressors. Unlike other strategies, targeted Nrf2 activation has the potential to simultaneously modulate separate pathological features of DMD to amplify therapeutic benefits. Here, we review the literature providing theoretical context for targeting Nrf2 as a disease modifying treatment against DMD.

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