Animal models are used with increasing numbers in the late LO phase and particularly in the candidate selection phase for pharmacokinetic/pharmacodynamic (PK/PD) and efficacy, and then also used in regulatory required safety studies. Therefore, there are opportunities throughout the drug discovery process to incorporate more translationally predictive cellular models, or CIVMs, to both reduce animal use aligned to our 3Rs commitment (replacement, reduction, and refinement) and provide data that better translate to the clinic, which ultimately results in better medicines for patients.
Elsevier,
How Sex and Gender Impact Clinical Practice, An Evidence-Based Guide to Patient Care, 2021, Pages 277-287
This book chapter advances SDGs 3 and 16 by examining three issues that are considered important public health issues as well as common patient problems—intimate partner violence, access to healthcare, and immunization—with a focus on sex and gender based medicine.
Elsevier,
Food Fraud, A Global Threat With Public Health and Economic Consequences, 2021, Pages 23-43
This book chapter addresses SDGs 3 and 10 by explaining US and EU regulatory requirements, Global Food Safety Initiative requirements, and reviews food fraud vulnerabiility.
World Soil Day (WSD) is held annually on 5 December as a means to focus attention on the importance of healthy soil and to advocate for the sustainable management of soil resources for a food-secure future. In support of this year's theme - 'Keep soil alive, protect soil biodiversity' - Elsevier presents a curated, open access collection of over 60 journal articles to raise awareness of the importance of maintaining healthy soil ecosystems.
Elsevier,
Solar PV Power, Design, Manufacturing and Applications from Sand to Systems, 2021, Pages 267-315
This book chapter addresses SDG 7 by explaining how off-grid solar photovoltaic systems aid in many industries including agriculature and shows the reliability and life cycle costing aspects.
Background: Research has revealed that survivors of childhood sexual abuse (CSA) have elevated sexual dysfunction and distress. Nevertheless, a vast majority of studies examining sexual dysfunction and distress among CSA survivors were conducted among women only, and the moderating role of post-traumatic stress disorder (PTSD) symptoms between a history of CSA and sexual dysfunction and distress is yet to be investigated.
This chapter advances SDG 6 by explaining the use of cluster analysis, multivariate statistical methods, principal component analysis, and factor analysis for the interpretation and analysis of difficult water quality data
This book chapter advances SDGs 3 and 17 by providing an overview of the characteristic features of neurodegenerative diseases, including AD and how to assess them to validate or to reject the suspected diagnosis.
Increased concern has recently emerged pertaining to the occurrence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in aquatic environment during the current coronavirus disease 2019 (COVID-19) pandemic. While infectious SARS-CoV-2 has yet to be identified in the aquatic environment, the virus potentially enters the wastewater stream from patient excretions and a precautionary approach dictates evaluating transmission pathways to ensure public health and safety.
Background: Various retrospective studies have reported on the increase of mortality risk due to higher diurnal temperature range (DTR). This study projects the effect of DTR on future mortality across 445 communities in 20 countries and regions. Methods: DTR-related mortality risk was estimated on the basis of the historical daily time-series of mortality and weather factors from Jan 1, 1985, to Dec 31, 2015, with data for 445 communities across 20 countries and regions, from the Multi-Country Multi-City Collaborative Research Network.
