Global

Neurodegenerative diseases (NDD) such as Alzheimer's (AD) and Parkinson's disease (PD) are distinct clinical entities; however, the aggregation of key neuronal proteins, presumably leading to neuronal demise appears to represent a common mechanism. It has become evident that advanced glycation end products (AGEs) trigger the accumulation of such modified proteins, which eventually contributes to the pathological aspect of NDDs. Increased levels of AGEs are found in amyloid plaques in AD brains and in both advanced and early PD (incidental Lewy body disease). The molecular mechanisms by which AGE dependent modifications may modulate the susceptibility towards NDDs, however, remain enigmatic and it is unclear whether AGEs may serve as biomarker of NDD. This study detected differential associations between NDD, sex and oxidative stress markers.

This book chapter advances SDG3 Good Health and Wellbeing and SDG10 Reducing Inequalities by examining the research on wearable mechatronic devices for upper-limb amputees.

This book chapter addresses goals 15, 13 and 11 by discussing how deserts are biodiverse places where life thrives in the extreme.