[Figure presented]Profs. Nik Kaltsoyannis and Steve Liddle joined the University of Manchester School of Chemistry in 2015 as co-directors of the Centre for Radiochemistry Research after having previously held chairs at, respectively, University College London and the University of Nottingham. They are also heads of computational and inorganic chemistry, respectively. Each has published ∼150 research articles, reviews, and book chapters and has extensive experience in f-element chemistry. Prof.
The detection of pharmaceuticals and endocrine disrupting compounds (EDCs), known as emerging contaminants (ECs), in the environment has attracted growing concern due to their toxicity and potential hazard to the ecosystems and humans. These contaminants are consumed at high quantities worldwide and they are released deliberately or accidentally into the water resources. The conventional treatment technologies that use biological processes cannot effectively remove these contaminants.
Elsevier, Sustainable Cities and Society, Volume 27, 1 November 2016
Water harvesting is an ancient practice that has been used, mainly in dry environments, to increase efficiency of water collection and use by directing water from a large natural watershed or man-made collection surface into a small basin where the water can be stored in underground reservoirs or to be used directly for irrigation or domestic uses. In modern era water harvesting has been neglected, particularly at the developed countries, due to the technological achievements in the fields of water production and transport.
World map of the 142 cities in the UrbMet database.
The sustainability of urban water systems is often compared in small numbers of cases selected as much for their familiarity as for their similarities and differences. Few studies examine large urban datasets to conduct comparisons that identify unexpected similarities and differences among urban water systems and problems. This research analyzed a dataset of 142 cities that includes annual per capita water use (m3/yr/cap) and population. It added a 0.5 ° grid annual water budget value (P-PET/yr) as an index of hydroclimatic water supply.
The Role of Gender-based Innovations for the UN Sustainable Development Goals: Toward 2030: Better Science and Technology for All (Edition 1)
The Elsevier Foundation is committed to advancing SDG 5 and has developed a 3-year strategic partnership with Portia, an organisation that women and men have the same opportunities for engagement and advancement in science. Building on research drawn from recent Gender Summits, Portia will advance sex-gender sensitive research, innovation, development and deeper understanding through a series of annual SDG reports and the creation of a Gender Summit Consortium.
The complexes of the mitochondrial respiratory chain.
Mitochondrial respiratory chain dysfunction causes a variety of life-threatening diseases affecting about 1 in 4300 adults. These diseases are genetically heterogeneous, but have the same outcome; reduced activity of mitochondrial respiratory chain complexes causing decreased ATP production and potentially toxic accumulation of metabolites. Severity and tissue specificity of these effects varies between patients by unknown mechanisms and treatment options are limited. So far most research has focused on the complexes themselves, and the impact on overall cellular metabolism is largely unclear. To illustrate how computer modelling can be used to better understand the potential impact of these disorders and inspire new research directions and treatments, we simulated them using a computer model of human cardiomyocyte mitochondrial metabolism containing over 300 characterised reactions and transport steps with experimental parameters taken from the literature. Overall, simulations were consistent with patient symptoms, supporting their biological and medical significance. These simulations predicted: complex I deficiencies could be compensated using multiple pathways; complex II deficiencies had less metabolic flexibility due to impacting both the TCA cycle and the respiratory chain; and complex III and IV deficiencies caused greatest decreases in ATP production with metabolic consequences that parallel hypoxia. Our study demonstrates how results from computer models can be compared to a clinical phenotype and used as a tool for hypothesis generation for subsequent experimental testing. These simulations can enhance understanding of dysfunctional mitochondrial metabolism and suggest new avenues for research into treatment of mitochondrial disease and other areas of mitochondrial dysfunction.

International Encyclopedia of Public Health (Second Edition), 2017, Pages 350-360

This chapter advances SDG 6 by explaining a multidisciplinary approach to drinking water from a public health perspective and how it is important as poverty, with its associated unsanitary living conditions and lack of access to water, proper nutrition, health care, and education, is the overwhelming determinant of infection and malnutrition.

International Encyclopedia of Public Health (Second Edition), 2017, Pages 388-401

This chapter advances SDG 6 by explaining water as it relates to human health.

International Encyclopedia of Public Health (Second Edition), 2017, Pages 148-158

This chapter advances SDG 6 by summarizing water contaminants (that have been included in current promulgated regulations) and emerging agents (that have been considered as contaminant candidates which may require further regulation), current regulations, and treatment options.
Elsevier, The Lancet, Volume 388, 8 October 2016