Global

There have been several recent studies addressing the genetic architecture of depression. This review serves to take stock of what is known now about the genetics of depression, how it has increased our knowledge and understanding of its mechanisms, and how the information and knowledge can be leveraged to improve the care of people affected.

Pyrolysis converts biomass into liquid, gaseous and solid fuels. This work reviews the existing models for biomass pyrolysis, including kinetic, network and mechanistic models. The kinetic models are based on the global reaction mechanisms and have been extensively used for a wide range of biomass under various operating conditions. Major emphases have been on the network models as these models predict the structural changes during biomass pyrolysis. Key aspects of various network models include reaction schemes, structural characteristics and applications to CFD simulations.

Perinatal depression (PND) is a heterogeneous disorder with differences in timing of onset of depression, which influences symptomology, severity, and treatment efficacy. Researchers must embrace the heterogeneity to bring fruition to a precision medicine approach for women in reproductive mental health care. Galea and Frokjaer discuss the heterogeneity of perinatal depression based on timing onset, which influences symptoms and has implications for etiology and treatment efficacy.

Elsevier, Advances in Radiation Oncology, Volume 4, April - June 2019
The proportion of female trainees in radiation oncology has generally declined despite increasing numbers of female medical students; as a result, radiation oncology is among the bottom 5 specialties in terms of the percentage of female applicants. Recently, social media has been harnessed as a tool to bring recognition to underrepresented groups within medicine and other fields.
This book chapter advances SDGs 3 and 17 by reviewing the neurochemical aspects of Alzheimer’s type of Dementia.
Elsevier,

Aging, Nutrition and Taste: Nutrition, Food Science and Culinary Perspectives for Aging Tastefully, 2019, Pages xi-xvi

The aging process changes the sensory sciences and can lead to malnutrition as eating becomes less pleasurable. This chapter explores how optimising food taste works toward ensuing ongoing good nutrition and health, contributing to SDGs 2 and 3.
Elsevier,

Sex Differences in Cardiovascular Physiology and Pathophysiology, Academic Press, 2019, Pages 41-59

The book chapter addresses SDG 5 by taking a comprehensive look into the often overlooked and underappreciated fundamental sex differences between men and women and how those differences affect the cardiovascular system.
Elsevier,

Sex Differences in Cardiovascular Physiology and Pathophysiology, Academic Press, 2019, Pages 185-201

This book chapter addresses SDG 3 and 5 by reviewing the differences in awareness, risk factors, pathophysiology, clinical presentation, diagnostic evaluation, and management between men and women with coronary artery disease (CAD).
More than 30 sterols/oxysterols/sterol-acids analysed in human CSF. 7α,25-Dihydroxy-3-oxocholest-4-en-26-oate reduced in AD patient-group. 7α,25-Dihydroxy-3-oxocholest-4-en-26-oate – an intermediate in bile acid synthesis. Bile acid synthesis linked to AD.
Elsevier,

SLAS Technology, Volume 24, 1 April 2019

Cystic fibrosis is a genetic disease affecting more than 70,000 people worldwide. Caused by a mutation in the CFTR gene, cystic fibrosis can result in difficulty breathing, widespread bacterial infections, edema, malnutrition, pancreatitis, and death. Current drug-based treatments struggle to reach the site of action due to the thick mucus, and only manage symptoms such as blocked airways, lung infections, and limited ability to digest food. Nanotechnology opens up possibilities for improved treatment strategies by focusing on drug penetration through the mucus lining, eliminating resulting bacterial infections, and targeting the underlying genetic cause of the disease. In this review, we present recent nanoparticle developments for cystic fibrosis, challenges in nanomedicine therapeutics, and future research directions in gene editing and nonviral vectors for gene delivery. 

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