Growing evidence suggests that the gut microbiome plays a crucial role in Alzheimer's disease (AD) pathogenesis through the microbiota-gut-brain axis, with alterations in gut microbiome composition linked to increased intestinal permeability, blood-brain barrier impairment, and neuroinflammation, and that gut microbiome modulation may alleviate AD symptoms, serve as a preventive measure, and also address comorbidities like Type 2 Diabetes Mellitus (T2DM), with future research directions including fecal microbiota transplantation (FMT) and precision medicine.
This review explores the potential therapeutic applications of the orexin system, focusing on its role as a target for treating various pathological conditions, including psychiatric and neurodegenerative diseases, and highlights the development of suvorexant as an orexin agent approved for insomnia treatment.
This article investigates the potential therapeutic effects of glutamic-oxaloacetic transaminase (GOT) in Alzheimer's disease (AD) by reducing glutamate concentrations in the hippocampi of mice, leading to improved neurological function, reduced β-amyloid protein levels, enhanced cognitive performance, increased neuron count and synaptic density, and altered protein expression, suggesting a promising treatment approach for early-stage AD.
This review artcile, with contributionsform allover the world, describes various approaches to convert plastic wastes into new products known as an efficient way to manage them and to enhance the sustainability of the environment.
The current review on atmospheric M/NPs is therefore focusing on sampling, sample preparation and identification methods. The approach will enable knowledge gaps to be identified, and recommendations to be made to support standardized and comparable future research
This study is a long-term monitoring study in which inter-seasonal relations are established. Thus, the spread of MP pollution in the region during the year was provided by an important bio-indicator.
The introduction of long-acting injectable pre-exposure prophylaxis adds to the choice of HIV-prevention options; this study assesses the potential impact of roll-out in the refion with the highest HIV burden.
Human immunodeficiency virus and Simian immunodeficiency (SIV) are highly immune evasive viruses with few vulnerabilities. Cytomegalovirus vector-programmed MHC-E-restricted CD8+ T cells can mediate complete replication arrest of primary SIV infection with subsequent viral clearance; this approach may be promising for putative vaccines or immuno-therapeutics against HIV.
Good paper on how electroencephalography monitoring is being used as a method to diagnose Alzheimer's.
TB is often reported in people with HIV, in whom isoniazid preventive therapy (IPT) is a treamtent regimen used to prevent TB infection. However, when mothers with HIV recieived IPT during their pregnancy, their babies were associated with an increased risk low birth weight, preterm birth, and becoming under weight. Males seemed to be particularly effected. This brings into question the use of IPT in pregnant women with HIV as the health-care communitry seeks to reach SDGs 3.1, 3.2, and 3.3.
