Elsevier, Social Science and Medicine, Volume 172, 1 January 2017
Rationale Much of the data on the acceptability of HIV Pre-Exposure Prophylaxis (PrEP) is based on willingness to take PrEP (i.e., hypothetical receptivity) rather than actual intentions (i.e., planned behavioral action) to do so. Objective We sought to examine differences between hypothetical willingness and behavioral intentions to begin PrEP in a national sample of gay and bisexual men (GBM) across the U.S.
Elsevier, Neurobiology of Sleep and Circadian Rhythms, Volume 2, 2017
To test the hypothesis that sleep can reverse cognitive impairment during Alzheimer's disease, we enhanced sleep in flies either co-expressing human amyloid precursor protein and Beta-secretase (APP:BACE), or in flies expressing human tau. The ubiquitous expression of APP:BACE or human tau disrupted sleep. The sleep deficits could be reversed and sleep could be enhanced when flies were administered the GABA-A agonist 4,5,6,7-tetrahydroisoxazolo-[5,4-c]pyridine-3-ol (THIP).
Elsevier, Neurobiology of Sleep and Circadian Rhythms, Volume 2, 2017
Sleep disorders are prevalent in Alzheimer's disease (AD) and a major cause of institutionalization. Like AD pathology, sleep abnormalities can appear years before cognitive decline and may be predictive of dementia. A bidirectional relationship between sleep and amyloid β (Aβ) has been well established with disturbed sleep and increased wakefulness leading to increased Aβ production and decreased Aβ clearance; whereas Aβ deposition is associated with increased wakefulness and sleep disturbances. Aβ fluctuates with the sleep-wake cycle and is higher during wakefulness and lower during sleep.
Elsevier, Chem, Volume 1, 1 December 2016
Professor Paul T. Anastas holds the Teresa and H. John Heinz II Chair in Chemistry for the Environment at Yale University and serves as director of the Center for Green Chemistry and Green Engineering at Yale. He has published widely on the subject of green chemistry and has served in the administration of three US presidents. Professor Julie Zimmerman is an internationally recognized engineer whose work is focused on advancing innovations in sustainable technologies.
Elsevier, Chem, Volume 1, 8 December 2016
Dr. Jeannette García is a chemist at IBM Research–Almaden. Her research focuses on the rational design of new polymers and materials through sustainable methods and targeting recyclable materials with previously inaccessible properties. García received her PhD in chemistry at Boston College in 2012 under the guidance of Dr. Amir H. Hoveyda and worked with Dr. Jim Hedrick as a postdoctoral researcher until 2013.
Elsevier, Physics Reports, Volume 664, 9 December 2016
Historically, infectious diseases caused considerable damage to human societies, and they continue to do so today. To help reduce their impact, mathematical models of disease transmission have been studied to help understand disease dynamics and inform prevention strategies. Vaccination–one of the most important preventive measures of modern times–is of great interest both theoretically and empirically. And in contrast to traditional approaches, recent research increasingly explores the pivotal implications of individual behavior and heterogeneous contact patterns in populations.
Elsevier, Science Bulletin, Volume 61, 1 December 2016
Future climate change is usually projected by coupled earth system models under specific emission scenarios designed by integrated assessment models (IAMs), and this offline approach means there is no interaction between the coupled earth system models and the IAMs. This paper introduces a new method to design possible future emission scenarios and corresponding climate change, in which a simple economic and climate damage component is added to the coupled earth system model of Beijing Normal University (BNU-ESM).
Elsevier, Kidney International, Volume 90, 1 December 2016
Evidence-based cinical practice guidelines improve delivery of uniform care to patients with and at risk of developing kidney disease, thereby reducing disease burden and improving outcomes. These guidelines are not well-integrated into care delivery systems in most low- and middle-income countries (LMICs). The KDIGO Controversies Conference on Implementation Strategies in LMIC reviewed the current state of knowledge in order to define a road map to improve the implementation of guideline-based kidney care in LMICs.
Elsevier, Urban Forestry and Urban Greening, Volume 20, 1 December 2016
Aquaponics is an innovative smart and sustainable production system for integrating aquaculture with hydroponic vegetable crops, that can play a crucial role in the future of environmental and socio-economic sustainability in smart cities. These cities aim mobilize all knowledge centers and Information and Communication Technologies (ICT) into innovation hubs in order to strengthen the socio-economic progress.