Elsevier,
Pharmacological Research, Volume 218, August 2025
The article provides a comprehensive overview of the role of the endogenous detoxification system in the pathogenesis of age-related neurodegenerative diseases, particularly Alzheimer's disease (AD) and Parkinson's disease (PD). It highlights epidemiological evidence linking environmental toxicant exposure to the onset and progression of these diseases, and discusses how dysfunction of detoxification pathways, including enzymes and transporters, can exacerbate neurodegenerative processes. The article also explores the potential of targeting nuclear receptor signaling pathways, such as the pregnane X receptor (PXR), as a promising therapeutic strategy to restore detoxification capacity and modify disease trajectories.
Elsevier,
Journal of Pharmacology and Experimental Therapeutics, Volume 392, August 2025
This review discusses the dual role of amyloid-beta (Aβ) in Alzheimer's disease (AD). While Aβ accumulation is a hallmark of AD pathology, soluble Aβ also plays a neuroprotective role in regulating synaptic plasticity and memory. The review explores the potential of anti-Aβ immunotherapy as a treatment strategy, highlighting the need to balance targeting toxic Aβ species while preserving the physiological functions of Aβ.`
Elsevier,
Journal of Prevention of Alzheimer's Disease, Volume 12, 1 August 2025
The study found that long-duration and high-intensity walking were associated with reduced amyloid-beta accumulation over 4 years, with the greatest benefits seen in those who started walking earlier in life. However, walking activity was not linked to changes in tau deposition, neurodegeneration, or white matter hyperintensities.
Elsevier,
Journal of Prevention of Alzheimer's Disease, Volume 12, 1 August 2025
The article estimates the value-based price of a blood test for Alzheimer's disease pathology, finding it would be $290-$1150 in primary care and $450-$1950 in specialty care, projecting substantial cost savings.
Elsevier, Journal of Allergy and Clinical Immunology, Volume 156, August 2025
This study investigated how host genetics and early-life environmental exposures influence the infant gut microbiota during the first year of life and its association with childhood asthma and allergic diseases by age 5 years. The researchers found that specific gut microbial changes and network clusters were associated with increased or decreased risk of asthma, wheeze, atopic dermatitis, and food/inhalant sensitization, with some associations being sex-specific
Elsevier, Journal of Allergy and Clinical Immunology, Volume 156, August 2025
This study examined how air pollution exposure affects asthma treatment effectiveness in Black children by reanalyzing data from the AsthmaNet BARD clinical trial. The researchers found that children with lower nitrogen dioxide (NO2) exposure had significantly better lung function improvements when treated with high-dose inhaled corticosteroids plus long-acting ?-agonists compared to children with higher NO2 exposure. The findings suggest that residential air pollution exposure, particularly NO2, may reduce the effectiveness of standard asthma treatments in Black children, highlighting the need to consider environmental factors in asthma management strategies.
Elsevier,
iScience, Volume 28, 15 August 2025
This perspective highlights strategies for modeling salt tolerance mechanisms, including root system architecture adaptation, salt filtration, adaptation of plant hydraulics, ion compartmentalization, and stomatal responses, to improve model representation and prediction.
Elsevier,
Current Developments in Nutrition, Volume 9, August 2025
The study demonstrates that adopting more climate-friendly diets, which typically involve reduced animal-based food consumption and lower absolute micronutrient intakes, does not substantially increase the risk of micronutrient deficiencies for most nutrients. These findings underscore the importance of assessing both dietary intake and actual nutrient status when evaluating the nutritional consequences of sustainable eating patterns, supporting the potential health and environmental benefits of shifting toward climate-friendly diets.
Elsevier,
Food Policy, Volume 135, August 2025
Low-income citizens show the highest support for food labeling and educational campaigns, viewing them as effective and less intrusive, while taxation and checkout prompts are least accepted due to perceived invasiveness. Policy support is strongly influenced by perceived effectiveness, intrusiveness, and individuals’ existing behaviors, suggesting tailored approaches are needed to improve acceptance and impact.
