Health and wellbeing

Health and well-being have a central role in the 17 Sustainable Development Goals (SDGs) endorsed by the United Nations, emphasizing the integral part they play in building a sustainable future. The third SDG explicitly calls for ensuring healthy lives and promoting well-being for all at all ages. This goal encompasses a wide range of health objectives, from reducing maternal and child mortality rates, combatting disease epidemics, to improving mental health and well-being. But beyond SDG 3, health is intrinsically linked with almost all the other goals.

When addressing SDG 1, which aims to end poverty, one cannot neglect the social determinants of health. Economic hardship often translates into poor nutrition, inadequate housing, and limited access to health care, leading to a vicious cycle of poverty and poor health. Similarly, achieving SDG 2, ending hunger, also contributes to better health through adequate nutrition, essential for physical and mental development and the prevention of various diseases.

Conversely, the repercussions of climate change, encapsulated in SDG 13, profoundly impact health. Rising global temperatures can lead to increased spread of infectious diseases, compromised food and water supplies, and increased frequency and intensity of extreme weather events, all posing severe health risks. Conversely, the promotion of good health can also mitigate climate change through the reduction of carbon-intensive lifestyles and adoption of healthier, more sustainable behaviors.

SDG 5, advocating for gender equality, also has substantial health implications. Ensuring women's access to sexual and reproductive health services not only improves their health outcomes, but also contributes to societal and economic development. Furthermore, achieving SDG 4, quality education, is also critical for health promotion. Education fosters health literacy, empowering individuals to make informed health decisions, hence improving overall community health.

Lastly, SDG 17 underlines the importance of partnerships for achieving these goals. Multi-sector collaboration is vital to integrate health considerations into all policies and practices. Stakeholders from various sectors, including health, education, agriculture, finance, and urban planning, need to align their efforts in creating sustainable environments that foster health and well-being.

Hence, the relationship between health, well-being, and the SDGs is reciprocal. Improving health and well-being helps in achieving sustainable development, and vice versa. In this context, health and well-being are not just outcomes but are also powerful enablers of sustainable development. For the world to truly thrive, it must recognize and act upon these interconnections.

Elsevier,

Zakim and Boyer's Hepatology (Seventh Edition), A Textbook of Liver Disease, 2018, Pages 77-83.e5

This chapter aligns with the SDG goal 3 of good health and wellbeing by showing the liver's response to injury including inflammation and fibrosis responses.
Access to water in Sub-Saharan Africa (SSA) continues to be a challenge to the extent that there are more people without access to water in 2015 than in 1990. This indicates that current approaches to water provision have been ineffective. Governments have failed to provide a structure, mechanisms or approaches that guarantee water for ALL, resulting in a vacuum which has been ‘filled’ by a number of social actors (NGOs, Faith Based Organisations, Donors).
The complexes of the mitochondrial respiratory chain.
Mitochondrial respiratory chain dysfunction causes a variety of life-threatening diseases affecting about 1 in 4300 adults. These diseases are genetically heterogeneous, but have the same outcome; reduced activity of mitochondrial respiratory chain complexes causing decreased ATP production and potentially toxic accumulation of metabolites. Severity and tissue specificity of these effects varies between patients by unknown mechanisms and treatment options are limited. So far most research has focused on the complexes themselves, and the impact on overall cellular metabolism is largely unclear. To illustrate how computer modelling can be used to better understand the potential impact of these disorders and inspire new research directions and treatments, we simulated them using a computer model of human cardiomyocyte mitochondrial metabolism containing over 300 characterised reactions and transport steps with experimental parameters taken from the literature. Overall, simulations were consistent with patient symptoms, supporting their biological and medical significance. These simulations predicted: complex I deficiencies could be compensated using multiple pathways; complex II deficiencies had less metabolic flexibility due to impacting both the TCA cycle and the respiratory chain; and complex III and IV deficiencies caused greatest decreases in ATP production with metabolic consequences that parallel hypoxia. Our study demonstrates how results from computer models can be compared to a clinical phenotype and used as a tool for hypothesis generation for subsequent experimental testing. These simulations can enhance understanding of dysfunctional mitochondrial metabolism and suggest new avenues for research into treatment of mitochondrial disease and other areas of mitochondrial dysfunction.
Global health threats such as the recent Ebola and Zika virus outbreaks require rapid and robust responses to prevent, reduce and recover from disease dispersion. As part of broader big data and digital humanitarianism discourses, there is an emerging interest in data produced through mobile phone communications for enhancing the data environment in such circumstances.
Elsevier,

International Encyclopedia of Public Health (Second Edition), 2017, Pages 556-562

Focuses on homelessness from a public health perspective – its prevalence, its relationship to specific health conditions, and various interventions intended to ameliorate homelessness and the health problems with which it is associated.
Elsevier,

Molecular and Cellular Endocrinology, Volume 434, 15 October 2016

This article ties to SDG 3. In this review, the impact of war-related trauma on the incidence of PTSD in civilian and military populations as well as differences associated to gender in the incidence and recovery from PTSD is discussed. In addition, the mutually influencing role of inflammation, genetic, and sex hormones in modulating the consequences derived from exposure to traumatic events are discussed in light of current evidence.
Elsevier,

International Encyclopedia of Public Health (Second Edition), 2017, Pages 434-443

This chapter advances goals 3 and 5 by examining the biological and social reasons women are disporportionately affected by mental health issues. It advocates for a gender-based approach to mental health programs to help women with the unique set of challenges they face.
Elsevier,

International Encyclopedia of Public Health (Second Edition), 2017, Pages 337-343

This article advances SDGs 3, 5, and 16 by providing a broad overview of global violence aginst women and highlighting the difference health professionals can make for women who experience violence in its multiple forms.
Elsevier,

International Encyclopedia of Public Health (Second Edition), 2017, Pages 491-498

This article advances SDGs 3, 5, and 16 by demonstrating how gender power inequalities are at the root of sexual violence against women and outlining ways to prevent sexual violence and mitigate the mental and physical health impacts of rape.
Young gay and bisexual men are at increased risk for human immunodeficiency virus (HIV) infection. Research suggests that the stress associated with being a stigmatized minority is related to negative mental health outcomes, substance use, and condomless sex. However, interventions aimed at reducing HIV risk behaviors in young gay and bisexual men have failed to address these important variables. The purpose of the present paper is to assist cognitive and behavioral therapists who work with young gay and bisexual men to conduct therapy for stress management and HIV prevention.

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