Elsevier,
Pharmacological Research, Volume 216, June 2025
The article discusses the potential of glucagon-like peptide-1 (GLP-1) receptor agonists (GRA) as novel therapeutic agents for neurodegenerative diseases (NDs) like Alzheimer's disease (AD) and Parkinson's disease (PD). GRA have shown promising effects in modulating neuroinflammation, oxidative stress, mitochondrial and autophagic functions, and protein misfolding in preclinical studies. Clinical trials have demonstrated that GRA like exenatide, liraglutide, and lixisenatide can improve motor deficits in PD and cognitive function in AD patients.
Elsevier,
Journal of Vascular Surgery, Volume 81, June 2025
This study indicates neurofibrillary tangles(NFT) level detection in patients with extracranial carotid atherosclerotic disease (ECAD) could enable earlier identification of those at high risk for developing Alzheimer's and other dementias, sometimes decades before symptoms. As blood-based assays to quantify NFT's are more clinically available, this could guide more targeted prevention and early treatment strategies for patients.
Elsevier,
Journal of Prevention of Alzheimer's Disease, Volume 12, 1 June 2025
The article discusses the need for and challenges of developing combination therapies for Alzheimer's disease, given the complex and multifactorial nature of the disease. As of 2024, there were 21 combination trials in the pipeline, primarily involving repurposed agents targeting processes like inflammation, senescence, and amyloid-tau interactions. Key challenges include distinguishing individual drug effects and managing the operational complexity of combination trials.f
Elsevier,
Linguistics and Education, Volume 87, June 2025
This study examines how multilingual elementary students use concept maps in an after-school science club to communicate scientific ideas, revealing that they position themselves as competent learners by making flexible language choices and incorporating personal experiences.
Elsevier,
World Development Sustainability, Volume 6, June 2025
This study examines the role of women’s leadership in the Wahana Usaha Jaya Cooperative in Bandung, Indonesia, in promoting household food waste reduction and community engagement. Findings show that WUJ’s spiritually motivated and economically empowering strategies effectively encourage waste reduction, particularly among women, despite ongoing infrastructural challenges. The study highlights that women-led, community-based cooperatives offer effective, context-sensitive models for urban environmental governance and advancing food security in the Global South.
Elsevier,
Current Biology, Volume 35, 9 June 2025
This study identified the gene PpNLR1 and its promoter variation as key factors conferring green peach aphid (GPA) resistance in peach, regulated by jasmonate-induced transcription factor PpERF109. Additionally, GPA salivary effectors activate the peach immune response through PpNLR1, offering valuable insights for breeding aphid-resistant peach cultivars.
Elsevier,
Journal of Nutrition, Health and Aging, Volume 29, June 2025
This study examines the impact of living conditions on cognitive function in older adults in China, and explores the role of plant-based dietary patterns in mitigating the negative effects of poor living conditions. The key finding is that living in fair or poor conditions was associated with an increased risk of developing cognitive impairment, and this association was more pronounced in the "Low-stable-decreasing PDI" group compared to the "High-rapid-decreasing PDI" group.
