Chagas disease, Human African Trypanosomiasis, and schistosomiasis are neglected parasitic diseases for which new treatments are urgently needed. To identify new chemical leads, we screened the 400 compounds of the Open Access Malaria Box against the cysteine proteases, cruzain (Trypanosoma cruzi), rhodesain (Trypanosoma brucei) and SmCB1 (Schistosoma mansoni), which are therapeutic targets for these diseases. Whereas just three hits were observed for SmCB1, 70 compounds inhibited cruzain or rhodesain by at least 50% at 5 μM.
Elsevier, Journal of Clinical Densitometry, Volume 22, October - December 2019
To answer important questions in the fields of monitoring with densitometry, dual-energy X-ray absorptiometry machine cross-calibration, monitoring, spinal cord injury, periprosthetic and orthopedic bone health, transgender medicine, and pediatric bone health, the International Society for Clinical Densitometry (ISCD) held a Position Development Conference from March 20 to 23, 2019. Potential topics requiring guidance were solicited from ISCD members in 2017. Following that, a steering committee selected, prioritized, and grouped topics into Task Forces.
Elsevier, Energy, Volume 185, 15 October 2019
Electricity systems based on renewables have an increasing demand for flexibility. This paper considers the potential of power-to-gas to provide flexibility and enhance system integration of renewables. Existing research on power-to-gas typically analyses the system effects of a predetermined power-to-gas unit without endogenising the investment decision. Moreover, insights related to market and portfolio effects of power-to-gas are rare. To this end this work presents a stochastic electricity market model.
Elsevier, One Earth, Volume 1, 25 October 2019
A new threat now confronts the Amazon in the form of a massive infrastructure program, the Initiative for the Integration of the Regional Infrastructure of South America, or IIRSA. This article presents results of a projection analysis showing that IIRSA could push the Amazonian forest past a “tipping point,” replacing it with tropical savanna. Such an event would degrade biodiversity, reduce carbon storage, and harm continental agriculture, dependent on moisture transport from forest-based rainfall recycling.
Elsevier, One Earth, Volume 1, 25 October 2019
Economic development projects are increasingly applying the mitigation hierarchy to achieve No Net Loss, or even a Net Gain, of biodiversity. Because people value biodiversity and ecosystem services, this can affect the well-being of local people; however, these types of social impacts from development receive limited consideration. We present ethical, practical, and regulatory reasons why development projects applying the mitigation hierarchy should consider related social impacts.
Elsevier, The Lancet Global Health, Volume 7, October 2019
Background: Globally, about 30% of women have experienced physical or sexual violence, or both, from an intimate partner during their lifetime. Associations between poverty and women's increased risk of intimate partner violence have been observed. We therefore aimed to assess the effect of a violence prevention intervention delivered to women participating in a group-based microfinance scheme in Tanzania. Methods: We did a cluster randomised controlled trial among women taking part in a microfinance loan scheme in Mwanza city, Tanzania.
Elsevier, One Earth, Volume 1, 25 October 2019
To conserve the bulk of Earth's ecological heritage across the Anthropocene, setting aside half of Earth's land is just a start. To conserve biodiversity over the long term across an increasingly human planet, conservation must become as integral to the human enterprise around the world as are social and economic development.
Elsevier, One Earth, Volume 1, 25 October 2019
Economic development projects are increasingly applying the mitigation hierarchy to achieve No Net Loss, or even a Net Gain, of biodiversity. Because people value biodiversity and ecosystem services, this can affect the well-being of local people; however, these types of social impacts from development receive limited consideration. We present ethical, practical, and regulatory reasons why development projects applying the mitigation hierarchy should consider related social impacts.
Economic development projects are increasingly applying the mitigation hierarchy to achieve No Net Loss, or even a Net Gain, of biodiversity. Because people value biodiversity and ecosystem services, this can affect the well-being of local people; however, these types of social impacts from development receive limited consideration. We present ethical, practical, and regulatory reasons why development projects applying the mitigation hierarchy should consider related social impacts.
Elsevier, Renewable and Sustainable Energy Reviews, Volume 113, October 2019
Accurate health estimation and lifetime prediction of lithium-ion batteries are crucial for durable electric vehicles. Early detection of inadequate performance facilitates timely maintenance of battery systems. This reduces operational costs and prevents accidents and malfunctions. Recent advancements in “Big Data” analytics and related statistical/computational tools raised interest in data-driven battery health estimation. Here, we will review these in view of their feasibility and cost-effectiveness in dealing with battery health in real-world applications.
