Articles

Change point analysis can reveal when a biomarker starts to diverge from the pattern of normal aging. This paper analyzes several biomarkers from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) to estimate the sequence and timing of their change points relative to a subsequent clinical diagnosis of mild cognitive impairment (MCI) in subjects initially considered cognitively normal (CN).

Based on the responses of a nationwide survey, this article explores the significant impact that COVID 19 has had on radiologists across the nation and, in the context of SDG 3, the impact on their mental health.

Background: Circadian disturbances are commonly seen in people with Alzheimer's disease and have been reported in individuals without symptoms of dementia but with Alzheimer's pathology. We aimed to assess the temporal relationship between circadian disturbances and Alzheimer's progression. Methods: We did a prospective cohort study of 1401 healthy older adults (aged >59 years) enrolled in the Rush Memory and Aging Project (Rush University Medical Center, Chicago, IL, USA) who had been followed up for up to 15 years.

In this brief perspective piece, a rural sexual assault nurse examiner (SANE) program is described in the hopes that dissemination will lead to increased numbers of rural SANEs, increased reporting of sexual assaults in rural and underserved communities, increased prosecution rates of sexual assault perpetrators, and program sustainability through the provision of a nurse-centered approach to training and support. This article contributes SDGs 3, 5, 9, and 16.