Elsevier, EBioMedicine, Volume 59, September 2020
Background: Cholinergic neuronal loss is one of the hallmarks of AD related neurodegeneration; however, preclinical promise of α7 nAChR drugs failed to translate into humans. CHRFAM7A, a uniquely human fusion gene, is a negative regulator of α7 nAChR and was unaccounted for in preclinical models. Methods: Molecular methods: Function of CHRFAM7A alleles was studied in vitro in two disease relevant phenotypic readouts: electrophysiology and Aβ uptake. Genome edited human induced pluripotent stem cells (iPSC) were used as a model system with the human context.
Elsevier, EBioMedicine, Volume 59, September 2020
Background: Recently, we reported that patients with mild cognitive impairment (MCI) harbor specific signature of bacteria in their gut and that a modified Mediterranean ketogenic diet (MMKD) improves Alzheimer's disease (AD) markers in cerebrospinal fluid (CSF) and the signatures of gut bacteria. However, other microbial population such as gut fungi (mycobiome) in relation to MCI/AD pathology, gut bacteria and diet remain unknown.

Case Studies in Chemical and Environmental Engineering, Volume 2, September 2020

As the global production of plastics continues to accelerate, the ubiquitous presence of microplastics (μPs) has emerged as a significant marine problem. To comprehend fully the potential impacts and ecological harm caused by μPs it is vital that there is an understanding of their potential sources and sinks; the processes affecting their distribution; and their uptake and exchange in ecosystems.


Journal of Mathematical Behavior, Volume 59, September 2020

Novel approach to the politics of mathematics disability, using historical and philosophical approaches. Use of western and indigenous examples of measurement practices. Rethinking the idea of colonial ‘settler’ mathematics.

Biomedical Signal Processing and Control, Volume 62, September 2020

Objective imaging-based biomarker discovery for psychiatric conditions is critical for accurate diagnosis and treatment. Using a machine learning framework, this work investigated the utility of brain's functional network topology (complex network features) extracted from functional magnetic resonance imaging (fMRI) functional connectivity (FC) as viable biomarker of autism spectrum disorder (ASD). To this end, we utilized resting-state fMRI data from the publicly available ABIDE dataset consisting of 432 ASD patients and 556 matched healthy controls.


Food Webs, Volume 24, September 2020

Ecology plays a central role in the management and conservation of ecosystems. However, as coral restoration emerges as an increasingly popular method of confronting the global decline of tropical coral reefs, an ecological basis to guide restoration remains under-developed. Here, we examine potential contributions that trophic ecology can make to reef restoration efforts. To do so, we conducted a comprehensive review of 519 peer-reviewed restoration studies from the past thirty years.

2018 First prize winner Dr. Prajwal Rajbhandari

17th September 2020

In 2018, Dr. Prajwal Rajbhandari was awarded the first prize of the Elsevier Foundation Green and Sustainable Chemistry Challenge for his project, “Guava leaves as natural preservatives for farmers of Nepal.” Due to a lack of viable non-toxic preservatives, or cold chain technologies, one-third of Nepal’s produce is spoiled before it reaches market each year. Dr. Rajbhandari’s project taps the antioxidant and antimicrobial properties of guava leaves to make a water-based, sprayable natural preservative, contributing to SDGs 2, 12 and 15. Two years later, we interviewed Dr. Rajbhandari about his experience as a winner, as well as the upcoming steps for his project.

The Lancet Global Health, Volume 8, September 2020

This study supports SDGs 3 and 6 by analysing data from 88 low-income and middle-income countries and showing geographical disparities in access to clean water and sanitation facilities. These findings identify where efforts to increase access to safe water and sanitation have been successful over time, and highlight the need for targeted and tailored interventions to reach those communities and regions that have been left behind.
Elsevier, One Earth, Volume 3, 18 September 2020
The recession and debt distress accompanying coronavirus disease 2019 (COVID-19) pose serious threats to governments’ ability to invest in achieving the Sustainable Development Goals, raising the specter of another lost decade for climate action. However, fiscal policy can be designed to simultaneously stabilize the economy and public finances while advancing sustainable development.