Articles

Evidence from preclinical research suggests that dysfunction in thyroid hormones may increase ?-amyloid levels and tau phosphorylation, 2 hallmark features of Alzheimer's Disease(AD). This study showed a strong association between hypothyroidism and AD mortality.

This article focuses on whether handwriting and typing contribute differentially to lexical acquisition within the alphabetic system, providing distinct sensorimotor experiences for words through different motor actions and consequent attentional and time constraints in producing letters. We examined a sample of middle school students with reading and spelling disabilities alongside age-matched peers with typical development.

Adsorption technology is an essential part of modern water treatment. However, only a handful of adsorbent materials are used industrially, which is in striking contrast with the exponentially increasing scientific publishing activity. In this perspective, the aim is to discuss the global progress on the adsorbent materials development by using the reported adsorption capacities as a simple probe. An automated text analyzer employing a large language model was used to extract adsorption data.

This article describes the discovery and characterization of FJMU1887, a novel brain-penetrant small-molecule inhibitor of Galectin-3 (Gal-3) identified through an AI-driven drug discovery platform. FJMU1887 demonstrated potent anti-inflammatory effects, reduced Aβ pathology, and improved cognitive function in Alzheimer's disease mouse models, highlighting its therapeutic potential for the treatment of Alzheimer's disease.