Elsevier,
Immunity, Volume 56, 12 September 2023
PLCγ2 is genetically linked to Alzheimer’s disease (AD), but it is unclear how PLCγ2 contributes to pathology. Tsai et al. demonstrate that AD-associated PLCG2 variants bidirectionally orchestrate microglial responses to plaques and impact neural function in an AD mouse model. This positions PLCγ2 as a key microglial signaling node and shows that targeting PLCγ2 could have therapeutic benefits in AD.
Elsevier,
The Lancet, Volume 402, 2 September 2023
This Comment article supports SDG 3, 6, and 16 by highlighting the structural and commercial determinants of water crises and their effects on health, and calls for international cooperation and solidarity to address power asymmetry, inequalities, and unaffordable access to water, putting human rights at the core of the water agenda.
Elsevier,
The Lancet. Public health, Volume 8, 1 September 2023
This Article supports Sustainable Development Goal 3 by calculating the proportion of dementia in Australia attributable to 11 potentially modifiable risk factors. They found that 38% of dementia was attributable to these risk factors (increasing to 41% when a 12th risk factor, traumatic brain injury, was added). The authors note that these findings could help to guide culturally specific dementia risk reduction programmes.
