Articles

Tauopathies are neurological disorders characterized by intracellular tau deposits forming neurofibrillary tangles, neuropil threads, or other disease-specific aggregates composed of the protein tau. Tauopathy disorders include frontotemporal lobar degeneration, corticobasal degeneration, Pick’s disease, and the largest cause of dementia, Alzheimer’s disease. The lack of disease-modifying therapeutic strategies to address tauopathies remains a critical unmet need in dementia care. Thus, novel broad-spectrum tau-targeted therapeutics could have a profound impact in multiple tauopathy disorders, including Alzheimer’s disease. Here we have designed a drug discovery paradigm to identify inhibitors of the pathological tau-enabling protein, MSUT2. We previously showed that activity of the RNA-binding protein MSUT2 drives tauopathy, including tau-mediated neurodegeneration and cognitive dysfunction, in mouse models. Thus, we hypothesized that MSUT2 inhibitors could be therapeutic for tauopathy disorders.

Material depletion over reliance of linear economies and environmental pollution may be resolved by applying the principles and practices of anthropogenic circularity science. Here we systematically review the emergence of anthropogenic circularity science in the interdisciplinary development of green chemistry, supply chain, and industrial ecology at different scales.

This article supports SDGs 7, 9 and 11 by utilizing solar photovoltaic, wind energy, solar thermal energy, and battery energy storage, and the special emphasis is placed on the schedulable value of concentrated solar power generation to provide more economical and environmentally friendly energy supply, while integrating multiple renewable energy technologies through artificial intelligence technology to shape the future of cities.

Blood donation saves lives, and the communication between blood centers and donors plays a vital role in this. Smart apps are now considered an important communication tool, and could be best utilized in blood donation if they are designed to fit the users’ needs and preferences.