Elsevier,
Journal of Prevention of Alzheimer's Disease, Volume 12, 1 June 2025
The article discusses the need for and challenges of developing combination therapies for Alzheimer's disease, given the complex and multifactorial nature of the disease. As of 2024, there were 21 combination trials in the pipeline, primarily involving repurposed agents targeting processes like inflammation, senescence, and amyloid-tau interactions. Key challenges include distinguishing individual drug effects and managing the operational complexity of combination trials.f
Elsevier,
IBRO Neuroscience Reports, Volume 18, June 2025
This study investigated the prevalence and impact of auditory agnosia for environmental sounds in individuals with Alzheimer’s disease (AD), finding that over half exhibited signs of this central auditory dysfunction along with a high rate of unrecognized peripheral hearing loss. Although these factors appeared independent and showed limited direct effect on measured quality of life, possibly due to sheltered living environments and lack of patient awareness, they jointly contribute to daily functional decline, highlighting the importance of early hearing assessment and intervention in AD management.
Elsevier,
Acta Pharmaceutica Sinica B, Volume 15, June 2025
The article discusses the critical role of the mitochondrial contact site and cristae organizing system (MICOS) complex in the pathogenesis of Alzheimer's disease (AD). It highlights how MICOS abnormalities, including subunit dysfunction and interactions with disease-associated proteins, to hallmark AD pathologies such as amyloid-β accumulation, neurofibrillary tangle formation, and neuronal apoptosis. The article suggests that targeting MICOS subunits with pharmacological interventions may provide novel therapeutic insights for AD treatment.
Elsevier,
Linguistics and Education, Volume 87, June 2025
This study examines how multilingual elementary students use concept maps in an after-school science club to communicate scientific ideas, revealing that they position themselves as competent learners by making flexible language choices and incorporating personal experiences.
Elsevier,
Current Biology, Volume 35, 9 June 2025
This study identified the gene PpNLR1 and its promoter variation as key factors conferring green peach aphid (GPA) resistance in peach, regulated by jasmonate-induced transcription factor PpERF109. Additionally, GPA salivary effectors activate the peach immune response through PpNLR1, offering valuable insights for breeding aphid-resistant peach cultivars.
Elsevier,
Journal of Nutrition, Health and Aging, Volume 29, June 2025
This study examines the impact of living conditions on cognitive function in older adults in China, and explores the role of plant-based dietary patterns in mitigating the negative effects of poor living conditions. The key finding is that living in fair or poor conditions was associated with an increased risk of developing cognitive impairment, and this association was more pronounced in the "Low-stable-decreasing PDI" group compared to the "High-rapid-decreasing PDI" group.
Elsevier,
World Development Sustainability, Volume 6, June 2025
This study examines the role of women’s leadership in the Wahana Usaha Jaya Cooperative in Bandung, Indonesia, in promoting household food waste reduction and community engagement. Findings show that WUJ’s spiritually motivated and economically empowering strategies effectively encourage waste reduction, particularly among women, despite ongoing infrastructural challenges. The study highlights that women-led, community-based cooperatives offer effective, context-sensitive models for urban environmental governance and advancing food security in the Global South.
