Elsevier, Telematics and Informatics Reports, Volume 14, June 2024
This paper addresses the underexplored environmental impacts of ICT by systematically reviewing 70 studies, identifying common assessment methods and mechanisms, and categorizing solutions into eight main classes within a comprehensive framework. It also evaluates how these solutions align with the UN Sustainable Development Goals, highlighting research gaps and policy implications to better mitigate ICT’s adverse environmental effects.
Journal of Pharmaceutical Analysis, 2024, 101022, ISSN 2095-1779
This study developed four deep learning models to identify potential Alzheimer's disease treatments from traditional Chinese medicine, specifically the Kaixinsan formula. The models successfully predicted compounds that showed significant anti-Alzheimer's activities in various experimental validations.
Elsevier,
Research in Globalization, Volume 8, June 2024
This article examines the development of a Nature Farming (NF) system standard for poultry production in Brazil, aiming to better communicate the sustainability attributes of NF products throughout the supply chain. Through qualitative research with various stakeholders, the study highlights the unique environmental, economic, social, ethical, and health dimensions of NF poultry and proposes clearer labeling and certification standards. The findings suggest that establishing a dedicated NF standard can enhance product differentiation, improve consumer communication, and support sustainable supply chain management.
Elsevier,
Neurochemistry International, Volume 176, June 2024
This study finds that impaired cellular immune dysfunction in AD patients was significantly correlated with abnormal MRS, and neuroimmune dysfunction may contribute to the pathogenesis of AD and alter the metabolism of neurotransmitters such as aspartic acid and MI in the brains of AD patients.
Elsevier,
Mechanisms of Ageing and Development, Volume 219, June 2024
This study identified key biochemical pathways and protein changes in the Alzheimer's disease (AD) human hippocampus, revealing increased expression of proteins VGF, GFAP, HSPB1, and APP, with UBC being most centrally involved, and highlighted the roles of four hub proteins (CD44, APP, ITGB2, APOE) linked to amyloid plaques and two (RPL24, RPS23) to neurofibrillary tangles, along with the impact of modified proteins on immune activation and synaptic disruption, uncovering potential therapeutic targets involving specific proteins, microRNAs, and transcription factors.
Elsevier,
Brain Research, Volume 1832, June 2024
Recent research on Alzheimer's disease (AD) suggests that microglia, immune cells in the brain, may play a beneficial role in early disease stages but become harmful in later stages due to various spatial, temporal, and transcriptional factors. Understanding the phenotypic heterogeneity and multiple states of microglia could lead to advancements in personalized medicine and improved treatment outcomes for AD patients.
