Articles

Elsevier,

Redox Biology, Volume 45, September 2021

Niemann-Pick type C (NPC) disease, a lysosomal storage disorder caused by defective NPC1/NPC2 function, results in the accumulation of cholesterol and glycosphingolipids in lysosomes of affected organs, such as liver and brain. Moreover, increase of mitochondrial cholesterol (mchol) content and impaired mitochondrial function and GSH depletion contribute to NPC disease. However, the underlying mechanism of mchol accumulation in NPC disease remains unknown. As STARD1 is crucial in intramitochondrial cholesterol trafficking and acid ceramidase (ACDase) has been shown to regulate STARD1, we explored the functional relationship between ACDase and STARD1 in NPC disease.
Elsevier,

Free Radical Biology and Medicine, Volume 173, September 2021

There is an urgent need to endorse a protective therapy for ALS patients. Possible treatments might be based on the underlying molecular pathophysiology. Some of the ALS dysregulated routes could be targeted by a single hit in NRF2. NRF2 emerged as a druggable target in preclinical and clinical trials for ALS.
Elsevier,

Environmental and Sustainability Indicators, Volume 11, September 2021

Scientists and governments of South Asian countries can work together more efficiently in the future, not just to react to the urban socio-economic and environmental problems of today, but work with superior foresight today to make strong decisions for tomorrow.
Elsevier,

The Journal of Climate Change and Health, Volume 4, 2021,100049

Given their carbon emissions, pharmaceutical companies must intensify their efforts and play an active role in addressing climate change.
Elsevier, Current Developments in Nutrition, Volume 5, 1 September 2021
This study demonstrates that systems science provides positive implementation approaches to design and translates nutrition behaviors and knowledge into practice.
Elsevier,

 

The Journal of Climate Change and Health, Volume 4, 2021, 100048

This exploratory study examines parental opinions about receiving climate change information at their child's checkup.
Elsevier,

 

The Journal of Climate Change and Health, Volume 4, 2021, 100048

This exploratory study examines parental opinions about receiving climate change information at their child's checkup.
Elsevier,

Mitochondrion, Volume 60, September 2021

Mitochondrial myopathy (MM) encompasses a clinical heterogenous group of patients that can be difficult to diagnose. This article investigates whether changes in plasma lactate concentration during a 6-minute submaximal handgrip test (6MHGT) and a 20-minute post-exercise recovery period can be used as a diagnostic test for MM.
Elsevier,

EBioMedicine, Volume 71, September 2021

An article on the pathology of Alzheimer's disease, in the context of SDG 3, focusing specifically on the potential use of an anti-cancer drug to modulate cerebrovascular angiogenesis as an alternative therapeutic strategy.
Schematic representations of the properties and functions of metal chelating agents.
Elsevier,

Journal of Trace Elements in Medicine and Biology, Volume 67, September 2021

Hypotheses for the pathogenesis of Alzheimer’s disease (AD) are described in this paper. The review is intended to be a basic and encyclopedic short insight into metals in AD and discusses the advances in chelation strategies and developments adopted in the treatment of the disease.

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