Global

Microglia play a key role in innate immunity in Alzheimer disease (AD), but their role as antigen-presenting cells is as yet unclear. Here we found that amyloid β peptide (Aβ)-specific T helper 1 (Aβ-Th1 cells) T cells polarized to secrete interferon-γ and intracerebroventricularly (ICV) injected to the 5XFAD mouse model of AD induced the differentiation of major histocompatibility complex class II (MHCII)+ microglia with distinct morphology and enhanced plaque clearance capacity than MHCII− microglia.

This Special Issue, bringing together articles from Science of the Total Environment; Renewable and Sustainable Energy Reviews; Ecological Modelling, and Resources; Conservation and Recycling, highlights the increasing understanding that major systems servicing human well-being, food, energy and water (FEW) systems are inextricably connected, and any attempt to address one dimension in isolation of the others will lead to unexpected, undesired, and far from optimal consequences. Considering these three systems holistically as the Food-Energy-Water Nexus directly considers Sustainable Development Goals 2 (zero hunger), 6 (clean water and sanitation), 7 (affordable and clean energy), 9 (industry, innovation and infrastructure), and 12 (responsible consumption and production).

Contributing to SDGs 2 and 3, this chapter argues that the use of specific foods to sustain or enhance overall health and wellness requires understanding and regulation to ensure realistic and optimal results.

This chapter addresses SDGs 3 and 10 by exploring the process of Disability-inclusive Disaster Risk Reduction (DiDRR) from two Deaf Disaster Risk Reduction (DRR) practitioners working in partnership with an international team.