, Gynecologic Oncology, Volume 153, June 2019
Background: While prophylactic human papillomavirus (HPV) vaccination exists, women are still developing cervical intraepithelial neoplasia (CIN) grade 2 or 3 for which an immunotherapeutic, non-surgical, approach may be effective. The primary aim was to assess the efficacy of tipapkinogen sovacivec (TS) vaccine in achieving histologic resolution of CIN2/3 associated with high risk (HR) HPV types. Methods: Women 18 years and older who had confirmed CIN2/3 were enrolled in a randomized, double blind, placebo-controlled phase II trial and assigned to drug in a 2:1 ratio (vaccine:placebo).
, Applied Nursing Research, Volume 47, June 2019
Young gay men are affected by HIV. Due to a lack of studies on these males, and that previous research notes youth's minimal healthcare seeking, we recruited young gay men at a gay men's STI testing clinic to explore their perceptions of care. Eight men participated in semi-structured interviews. Our results identified that, while our participants experienced stigma in some interactions, particularly when healthcare workers emphasized the probability of contracting HIV for gay men, overall they reported positive experiences with healthcare providers, particularly at the gay men's STI clinic.
, Social Science and Medicine, Volume 230, June 2019
Rationale: Transgender people face unique challenges, such as structural, interpersonal, and individual vulnerabilities to chronic diseases. Stigma and prejudice may hamper their access to health care and prevent their inclusion in the labor market, as well as cause exposition to violence. Labor market exclusion contributes to engagement in survival sex work, which increases HIV infection vulnerability.
, Journal of School Psychology, Volume 74, June 2019
Inclusive policies that attend to sexual orientation and gender identity (SOGI) are associated with more supportive school environments for lesbian, gay, bisexual, and transgender (LGBT) youth. We use the 2013–2015 California Healthy Kids Survey (n = 113,148) matched with principal reports of school policies from the 2014 California School Health Profiles to examine differential effects of SOGI-focused policies for LGB and transgender youth.
, Current Opinion in Environmental Sustainability, Volume 38, June 2019
A growing movement of conservationists proposes to stem biodiversity losses by setting aside half of Earth's land as an interconnected global conservation reserve. As the largest land governance proposal in history, Half Earth engages with some of the wickedest challenges in land system science. How best to allocate and manage Earth's land to maximize biodiversity conservation in the face of competing demands for food, housing and other human needs? Can half of Earth's land be reallocated and governed fairly and equitably in ways that honor the rights of vulnerable populations?
, Current Opinion in Insect Science, Volume 33, June 2019
Insect populations are declining even in protected areas, but the underlying causes are unclear. Here, I consider whether the factors driving the loss of insect diversity include invasive and/or introduced insects transmitting pathogens to less-resistant native species. The introduction of insects into new areas for biocontrol, to promote pollination, or for mass rearing in insect farms, threatens the health and diversity of indigenous insects by the co-introduction of entomopathogens whose spillover is difficult to control.
, Biomass and Bioenergy, Volume 125, June 2019
Rising demand for renewable resources has increased silage maize (Zea mays L.)production characterized by intensive soil management, high fertilizer and pesticide inputs as well as simplified crop rotations. Advantages of renewable biomass production may thus be cancelled out by adverse environmental effects. Perennial crops, like cup plant (Silphium perfoliatum L.), are said to benefit arthropods. Substituting silage maize could hence increase biodiversity and foster ecosystem services.
, World Development, Volume 118, June 2019
Understanding the politics of education reform is crucial to assess the challenges facing the SDG of quality education. This article surveys the small academic literature on the politics of reform as well as a wide range of empirical research on reform experiences across the world, with an emphasis on recent reforms in Latin America. We focus on teacher policy reforms, which play a central role in raising learning in primary and secondary schools, but pose three special challenges.
, World Development, Volume 118, June 2019
The 2030 Agenda for Sustainable Development is ambitious and inclusive, but how well are these global aspirations likely to result in implementable policy change for water and sanitation? This article assesses governance challenges at the local level associated with Sustainable Development Goal (SDG) 6, which pledges to ensure sustainable water and sanitation for all. The majority of developing countries manage services at the subnational level, making the quality of local governance the key ingredient for improvements in the sector.
, Molecular and Cellular Neuroscience, Volume 97, June 2019
The aggregation of fibrils of hyperphosphorylated and C-terminally truncated microtubule-associated tau protein characterizes 80% of all dementia disorders, the most common neurodegenerative disorders. These so-called tauopathies are hitherto not curable and their diagnosis, especially at early disease stages, has traditionally proven difficult. A keystone in the diagnosis of tauopathies was the development of methods to assess levels of tau protein in vivo in cerebrospinal fluid, which has significantly improved our knowledge about these conditions.