Elsevier,
Redox Biology, Volume 62, June 2023
SCFA contribute to the glutamate-glutamine shuttle by acting on glutamine synthetase. Long-term SCFA diet alleviates cognitive and spatial memory defeat in APP/PS1 mice. Long-term SCFA diet reduces Aβ deposition and abnormal phosphorylation of tau. SCFA promote astrocyte-neuron metabolic coupling to reduce oxidative damage.
Elsevier,
SLAS Discovery, Volume 28, June 2023
In this study, a novel reporter substrate named C8CF3-coumarin was synthesized and then characterized, an assay protocol was developed to identify small molecular activators of PLCγ enzymes, and a proof-of-principle high throughput screen was conducted using PLCγ2 and the LOPAC1280 library. These studies showed that C8CF3-coumarin could indeed monitor PLCγ enzyme activity and identify potential small molecule activators from a screen. The identification of such small molecule PLCγ2 activators would be of great utility to the Alzheimer's disease research community by serving as both chemical probes to study the modulation of PLCγ2 and as potential therapeutic agents.
Earth-Science Reviews, Volume 240, May 2023
Monitoring the ocean carbon cycle is key to improved understanding. Satellites play a major role in our global carbon monitoring system. To make full use of satellite observations for ocean carbon monitoring the remote-sensing community needs to work closely with in-situ data experts, physical and biogeochemical modellers, Earth system scientists, climate scientists and marine policy experts.
Elsevier, Transportation Research Part D: Transport and Environment, Volume 118, May 2023
Increasing shipping traffic in the Arctic Ocean creates an emerging need to understand the consequences of maritime operations on the Arctic environment and coastal Indigenous and non-Indigenous communities, as well as potential governance responses. To address this need, we examine recent shipping trends and assess their impact on Arctic environments and communities. Our arguments are novel, and are built around contemporary empirical investigations and published scientific studies, reports, and government documents.
Fisheries Research, Volume 265, 2023, 106744
A critical reflection on fisheries conservation in the Mekong River is offered here. Adaptive co-management helped balance conservation and livelihood outcomes. No-take zones facilitated basic fish conservation measures led by local fishermen. Fishermen perceiving livelihood benefits of conservation supported no-take zones. Long-term mechanisms to support community-led conservation initiatives are needed.
Elsevier,
The Lancet Regional Health - Western Pacific, Volume 34, May 2023
This Article supports SDG 3 by highlighting the effectiveness of a co-designed intervention for providing First Nations care within Western health services, which could address current gaps in respiratory health outcomes for Aboriginal children.
Elsevier,
Current Developments in Nutrition, Volume 7, May 2023
The authors of this paper developed and tested a culturally appropriate food picture-sort frequency tool that is feasible and acceptable to both Navajo children and adults. This tool and its indices have the potential to measure the change for school-based intervention studies among the Navajo Nation because of its cultural appropriateness, ease of administration and low burden, and the convergent validity and reliability of its indices.
Elsevier,
Lancet Regional Health - Americas, Volume 21, May 2023
This Article supports SDG 3 and 10 by showing that among Indigenous children in Brazil (of the Guarani birth cohort), severely compromised living conditions were noted, and inequalities in the frequency of social and environmental risk factors between the Indigenous children. The authors note that policies are needed to improve housing, water and sanitation, and wealth conditions among people in Indigenous communities.
Elsevier,
Current Developments in Nutrition, Volume 7, May 2023
This paper concludes that In the participating Dene population, vitamin D, fiber, and calcium intake were low, resulting in deficiencies for the majority of the participants and that Poor nutritional status might be because of several complex and intersecting challenges experienced by northern Indigenous communities, such as the historical context of colonialism, remote food insecurity, and social and environmental inequities. It is suggested that nutrition education, financial interventions, and store-food pricing policies should be put in place to facilitate access to market food, and culturally adequate initiatives, such as community harvest programs, should be put in place to facilitate better access to TFs/CFs.
