Elsevier, Physics and Chemistry of the Earth, Volume 122, June 2021
Since the 1980s, the industrialization and urbanization of the Beijing area has entered a period of high-speed growth. This paper asks the question: How have such great changes in urban land-use over the past decades impacted urban precipitation? In this study, we investigate and analyze the effects of urbanization on the summer precipitation in Beijing using numerical modeling approaches. Applying the numerical mesoscale atmospheric model METRAS, we determine the impact of surface cover on 13 heavy precipitation events.
Elsevier, Journal of Asian Earth Sciences: X, Volume 5, 1 June 2021
Along with the impact of energy structure adjustment as well as the coal resource exhaustion in the old mining region, the deformation over the abandoned mine region has severely restricted both the reuse of abandoned lands and the sustainable urban development. Therefore, it is essential to conduct the long-term surface deformation observation in the abandoned coal region.
Elsevier,
The Lancet Planetary Health, Volume 5, June 2021
Temperature affects many life processes, but its effect might be expected to differ among eukaryotic organisms inhabiting similar environments. We reviewed literature on temperature thresholds of humans, livestock, poultry, agricultural crops, and sparse examples of fisheries. We found that preferable and harmful temperatures are similar for humans, cattle, pigs, poultry, fish, and agricultural crops. Preferable temperatures range from 17°C to 24°C. Stress temperature thresholds are lower when humidity is higher.
Elsevier,
EClinicalMedicine, Volume 36, June 2021
A Commentary on the role of governments in mitigating the health effects of malnutrition, in the context of SDGs 3 and 12, highlighting the need for the implementation of more comprehensive policies to limit the availability of unhealthy foods and to increase that of healthy foods to communities across Africa.
Elsevier, The Lancet Public Health, Volume 6, June 2021
Background: The COVID-19 pandemic has affected mental health, psychological wellbeing, and social interactions. People with physical disabilities might be particularly likely to be negatively affected, but evidence is scarce. Our aim was to evaluate the emotional and social experience of older people with physical disabilities during the early months of the COVID-19 pandemic in England.
Elsevier, Heliyon, Volume 7, June 2021
Background: Viral hepatitis could have an impact on the treatment response in HIV patients. In this study, we sought to determine the prevalence of hepatitis B and C infections and examine the effect on the treatment response in HIV-1 patients attending antiretroviral therapy (ART) centers in the Volta and Oti Regions of Ghana. Method: A longitudinal study design was employed.
Elsevier,
SLAS Discovery, Volume 26, June 2021
The pharmacologic parameters that drive optimal HIV latency reversal in vivo are unknown and could be influenced by such factors as the HDACi binding kinetics, concentration of compound, and duration of exposure. This study evaluates how these parameters affect HIV latency reversal for a series of novel HDACis that differ in their enzymatic on and off rates. The comprehensive data set generated by automating the assays described here was used to establish a PK/PD model for HDACi-induced HIV latency reversal.
SLAS Discovery, Volume 26, June 2021
Collaborative efforts between public and private entities such as academic institutions, governments, and pharmaceutical companies form an integral part of scientific research, and notable instances of such initiatives have been created within the life science community. Several examples of alliances exist with the broad goal of collaborating toward scientific advancement and improved public welfare. Such collaborations can be essential in catalyzing breaking areas of science within high-risk or global public health strategies that may have otherwise not progressed. A common term used to describe these alliances is public-private partnership (PPP). This review discusses different aspects of such partnerships in drug discovery/development and provides example applications as well as successful case studies. Specific areas that are covered include PPPs for sharing compounds at various phases of the drug discovery process—from compound collections for hit identification to sharing clinical candidates. Instances of PPPs to support better data integration and build better machine learning models are also discussed. The review also provides examples of PPPs that address the gap in knowledge or resources among involved parties and advance drug discovery, especially in disease areas with unfulfilled and/or social needs, like neurological disorders, cancer, and neglected and rare diseases.
Elsevier, Journal of Pediatric Nursing, Volume 58, 1 May 2021
Problem: Today, one in four children in the world lives in an area of conflict or disaster, and more than 30 million have been displaced, enslaved or trafficked, abused, and exploited. However, there is little recognition of nursing interventions in this context and their impact on the quality of life. Eligibility Criteria: Studies that (1) Described nursing interventions in children under situations of armed conflict. (2) Identified the impact of the interventions in the Quality of Life. (3) identify research trends in the field by nursing professionals.
