Articles

In vivo triple transgenic AD mouse model brains and retinas showed hypoxic vessels expressing hypoxyprobe and HIF-1α. In in vitro OGD-treated endothelial cells, HIF-1α upregulated NADPH oxidase (NOX) (i.e., Nox2, Nox4). NLRP1 protein was promoted by OGD, and such effect was blocked by downregulation of Nox4 and HIF-1α. Hypoxic endothelial cells of AD brains and retinas markedly expressed NLRP1, ASC, caspase-1, and interleukin-1β (IL-1β). Chronic hypoxia in microvascular endothelial cells leads to HIF-1α-NLRP1 circuit in AD.

The short comment supports SDGs 12 and 13 and advocates the concept of LIFE that focusses on an individual's responsibility to utilise resources mindfully and contribute their share to saving the planet. This concept was introduced by the Indian government at COP 26

This study supports SDGs 9 and 15. The permafrost on the Tibetan Plateau has been significantly degraded becuase of global warming. This article assessed the future stability of the Qinghai-Tibet Railway.

The demand for solar energy as a clean way to power human lives is increasing, but solar panels are land-intensive and may compete for space with farms. In this article, the authors examine how agrivoltaics (combining farming and solar technologies) can provide synergistic benefits together rather than in isolation, showing positive benefits in climate mitigation, climate resilience, and land equivalent ratios. This contributes to SDGs 2 (ensuring the promotion of sustainable agriculture), 7 (harnessing sunlight to power society), and 13 (agrivoltaics as a way to combat climate change).