Elsevier, Sustainable Cities and Society, Volume 28, 1 January 2017
Urban water management via Sustainable Urban Drainage Systems (SuDS) has been successfully applied in cities worldwide. This infrastructure has proven to be a cost efficient solution to manage flood risks whilst also delivering wider benefits. Despite their technical performance, large-scale SuDS uptake in many places has been slow, mostly due to reasons beyond the engineering realm. This is the case of England and Wales, where the implementation of SuDS has not reached its full potential.
Elsevier, Sustainable Cities and Society, Volume 28, 1 January 2017
An international review of stormwater regulation and practices, especially for low-exposure, landscape irrigation schemes in urban environments, was undertaken with a view to identifying what could be used in Alberta, Canada. A general lack of clear guidance and regulation to manage stormwater quality and potential public health risks was identified, which could be hindering the uptake of stormwater schemes generally.
Elsevier, Sustainable Cities and Society, Volume 28, 1 January 2017
Urban source separation infrastructure systems have a promising potential for a more sustainable management of household food waste and wastewaters. A renewed trend of larger implementations of pilot areas with such systems is currently emerging in Northern Europe. This study investigates the drivers behind the decision of stakeholders to implement source separation systems as well as the importance of the previously existing pilot areas in the decision-making process. By means of semi-structured expert interviews, five areas with source separation were characterized and compared.
Elsevier, Renewable and Sustainable Energy Reviews, Volume 76, 2017
An effective response to climate change demands rapid replacement of fossil carbon energy sources. This must occur concurrently with an ongoing rise in total global energy consumption. While many modelled scenarios have been published claiming to show that a 100% renewable electricity system is achievable, there is no empirical or historical evidence that demonstrates that such systems are in fact feasible. Of the studies published to date, 24 have forecast regional, national or global energy requirements at sufficient detail to be considered potentially credible.
Elsevier, Social Science and Medicine, Volume 172, 1 January 2017
Rationale Much of the data on the acceptability of HIV Pre-Exposure Prophylaxis (PrEP) is based on willingness to take PrEP (i.e., hypothetical receptivity) rather than actual intentions (i.e., planned behavioral action) to do so. Objective We sought to examine differences between hypothetical willingness and behavioral intentions to begin PrEP in a national sample of gay and bisexual men (GBM) across the U.S.
Elsevier, Neurobiology of Sleep and Circadian Rhythms, Volume 2, 2017
To test the hypothesis that sleep can reverse cognitive impairment during Alzheimer's disease, we enhanced sleep in flies either co-expressing human amyloid precursor protein and Beta-secretase (APP:BACE), or in flies expressing human tau. The ubiquitous expression of APP:BACE or human tau disrupted sleep. The sleep deficits could be reversed and sleep could be enhanced when flies were administered the GABA-A agonist 4,5,6,7-tetrahydroisoxazolo-[5,4-c]pyridine-3-ol (THIP).
Elsevier, Neurobiology of Sleep and Circadian Rhythms, Volume 2, 2017
Sleep disorders are prevalent in Alzheimer's disease (AD) and a major cause of institutionalization. Like AD pathology, sleep abnormalities can appear years before cognitive decline and may be predictive of dementia. A bidirectional relationship between sleep and amyloid β (Aβ) has been well established with disturbed sleep and increased wakefulness leading to increased Aβ production and decreased Aβ clearance; whereas Aβ deposition is associated with increased wakefulness and sleep disturbances. Aβ fluctuates with the sleep-wake cycle and is higher during wakefulness and lower during sleep.
