Articles

Elsevier, EBioMedicine, Volume 59, September 2020
Background: Cholinergic neuronal loss is one of the hallmarks of AD related neurodegeneration; however, preclinical promise of α7 nAChR drugs failed to translate into humans. CHRFAM7A, a uniquely human fusion gene, is a negative regulator of α7 nAChR and was unaccounted for in preclinical models. Methods: Molecular methods: Function of CHRFAM7A alleles was studied in vitro in two disease relevant phenotypic readouts: electrophysiology and Aβ uptake. Genome edited human induced pluripotent stem cells (iPSC) were used as a model system with the human context.
Elsevier, EBioMedicine, Volume 59, September 2020
Background: Recently, we reported that patients with mild cognitive impairment (MCI) harbor specific signature of bacteria in their gut and that a modified Mediterranean ketogenic diet (MMKD) improves Alzheimer's disease (AD) markers in cerebrospinal fluid (CSF) and the signatures of gut bacteria. However, other microbial population such as gut fungi (mycobiome) in relation to MCI/AD pathology, gut bacteria and diet remain unknown.
Elsevier,

Food Webs, Volume 24, September 2020

Ecology plays a central role in the management and conservation of ecosystems. However, as coral restoration emerges as an increasingly popular method of confronting the global decline of tropical coral reefs, an ecological basis to guide restoration remains under-developed. Here, we examine potential contributions that trophic ecology can make to reef restoration efforts. To do so, we conducted a comprehensive review of 519 peer-reviewed restoration studies from the past thirty years.

Elsevier,

Biomedical Signal Processing and Control, Volume 62, September 2020

Objective imaging-based biomarker discovery for psychiatric conditions is critical for accurate diagnosis and treatment. Using a machine learning framework, this work investigated the utility of brain's functional network topology (complex network features) extracted from functional magnetic resonance imaging (fMRI) functional connectivity (FC) as viable biomarker of autism spectrum disorder (ASD). To this end, we utilized resting-state fMRI data from the publicly available ABIDE dataset consisting of 432 ASD patients and 556 matched healthy controls.

Elsevier,

Case Studies in Chemical and Environmental Engineering, Volume 2, September 2020

As the global production of plastics continues to accelerate, the ubiquitous presence of microplastics (μPs) has emerged as a significant marine problem. To comprehend fully the potential impacts and ecological harm caused by μPs it is vital that there is an understanding of their potential sources and sinks; the processes affecting their distribution; and their uptake and exchange in ecosystems.

Elsevier,

Journal of Mathematical Behavior, Volume 59, September 2020

Novel approach to the politics of mathematics disability, using historical and philosophical approaches. Use of western and indigenous examples of measurement practices. Rethinking the idea of colonial ‘settler’ mathematics.
Elsevier,

Transportation Research Part A: Policy and Practice, Volume 139, September 2020

Although the last decades have seen an advance in equality and empowerment for women, there are still numerous challenges to be addressed. Among them, and particularly pressing in cities, are issues of gender-based violence, including sexual harassment in public spaces. Despite the numerous effects that street harassment has on women, and the high incidence of it in different countries, this issue has not been broadly studied, and even less so in cities in the Global South.

Elsevier,

International Journal of Hygiene and Environmental Health, Volume 230, September 2020

Background: Access to safe sanitation and the elimination of open defecation are pre-conditions for improved child health and nutrition and wider achievement of the Sustainable Development Goals (SDGs). While Indonesia has a solid policy framework, the country ranks third globally in terms of numbers of people practicing open defecation. Objectives: Our aim was to assess the effectiveness of a five-year strategy to reduce open defecation through accelerating implementation of the national sanitation program across districts receiving variable levels of external support.

2018 First prize winner Dr. Prajwal Rajbhandari
Elsevier,

17th September 2020

In 2018, Dr. Prajwal Rajbhandari was awarded the first prize of the Elsevier Foundation Green and Sustainable Chemistry Challenge for his project, “Guava leaves as natural preservatives for farmers of Nepal.” Due to a lack of viable non-toxic preservatives, or cold chain technologies, one-third of Nepal’s produce is spoiled before it reaches market each year. Dr. Rajbhandari’s project taps the antioxidant and antimicrobial properties of guava leaves to make a water-based, sprayable natural preservative, contributing to SDGs 2, 12 and 15. Two years later, we interviewed Dr. Rajbhandari about his experience as a winner, as well as the upcoming steps for his project.

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